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    mttpmtp-antibody-ab63467.pdf

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Signal Transduction Metabolism Lipid metabolism
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Anti-MTTP/MTP antibody (ab63467)

  • Datasheet
Submit a review Submit a question References (3)

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Western blot - Anti-MTTP/MTP antibody (ab63467)
  • Immunocytochemistry/ Immunofluorescence - Anti-MTTP/MTP antibody (ab63467)

Key features and details

  • Rabbit polyclonal to MTTP/MTP
  • Suitable for: ICC/IF, WB
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-MTTP/MTP antibody
    See all MTTP/MTP primary antibodies
  • Description

    Rabbit polyclonal to MTTP/MTP
  • Host species

    Rabbit
  • Tested Applications & Species

    Application Species
    ICC/IF
    Human
    WB
    Human
    See all applications and species data
  • Immunogen

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • Positive control

    • This antibody gave a positive signal in Human Liver Tissue Lysate.
  • General notes

     This product was previously labelled as MTTP

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituent: PBS

    Batches of this product that have a concentration < 1mg/ml may have BSA added as a stabilising agent. If you would like information about the formulation of a specific lot, please contact our scientific support team who will be happy to help.
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipoproteins/Apolipoproteins
    • Apolipoproteins
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab63467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Guaranteed

Tested applications are guaranteed to work and covered by our Abpromise guarantee.

Predicted

Predicted to work for this combination of applications and species but not guaranteed.

Incompatible

Does not work for this combination of applications and species.

Application Species
ICC/IF
Human
WB
Human
All applications
Cow
Application Abreviews Notes
ICC/IF
Use a concentration of 1 µg/ml.
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).
Notes
ICC/IF
Use a concentration of 1 µg/ml.
WB
Use a concentration of 1 µg/ml. Detects a band of approximately 99 kDa (predicted molecular weight: 99 kDa).

Target

  • Function

    Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.
  • Tissue specificity

    Liver and small intestine. Also found in ovary, testis and kidney.
  • Involvement in disease

    Abetalipoproteinemia
  • Sequence similarities

    Contains 1 vitellogenin domain.
  • Cellular localization

    Endoplasmic reticulum.
  • Target information above from: UniProt accession P55157 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 4547 Human
    • Omim: 590075 Human
    • SwissProt: P55156 Cow
    • SwissProt: P55157 Human
    • Unigene: 195799 Human
    • Alternative names

      • ABL antibody
      • Microsomal triglyceride transfer protein (large polypeptide 88kDa) antibody
      • Microsomal triglyceride transfer protein 88kD antibody
      • Microsomal triglyceride transfer protein antibody
      • Microsomal triglyceride transfer protein large subunit antibody
      • MTP antibody
      • MTP large subunit antibody
      • MTP_HUMAN antibody
      • MTTP antibody
      • Transfer RNA, mitochondrial, proline antibody
      • tRNA-Pro, mitochondrial antibody
      see all

    Images

    • Western blot - Anti-MTTP/MTP antibody (ab63467)
      Western blot - Anti-MTTP/MTP antibody (ab63467)
      Anti-MTTP/MTP antibody (ab63467) at 1 µg/ml + Liver (Human) Tissue Lysate at 10 µg

      Secondary
      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 99 kDa
      Observed band size: 99 kDa


      Exposure time: 20 minutes
    • Immunocytochemistry/ Immunofluorescence - Anti-MTTP/MTP antibody (ab63467)
      Immunocytochemistry/ Immunofluorescence - Anti-MTTP/MTP antibody (ab63467)

      ICC/IF image of ab63467 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab63467 at 1µg/ml overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti- rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 100% Methanol fixed (5min) HeLa cell types at 1ug/ml

    Protocols

    • Western blot protocols
    • Immunocytochemistry & immunofluorescence protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (3)

    Publishing research using ab63467? Please let us know so that we can cite the reference in this datasheet.

    ab63467 has been referenced in 3 publications.

    • Hu L  et al. Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles. Antiviral Res 148:5-14 (2017). PubMed: 29074218
    • Bai J  et al. Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes. Toxicol Rep 3:98-104 (2016). PubMed: 28959527
    • Yamamoto Y  et al. Rapid alternative absorption of dietary long-chain fatty acids with upregulation of intestinal glycosylated CD36 in liver cirrhosis. Am J Clin Nutr 96:90-101 (2012). Human . PubMed: 22648712

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