Key features and details
- Rabbit polyclonal to MUC17
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MUC17 antibody
DescriptionRabbit polyclonal to MUC17
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
antigen sequence, corresponding to amino acids 4122-4262 of Human MUC17.
- Human small intestine tissue.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), 59% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab122184 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/500 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionProbably plays a role in maintaining homeostasis on mucosal surfaces.
Tissue specificityExpressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.
Sequence similaritiesContains 1 EGF-like domain.
Contains 1 SEA domain.
modificationsProbably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
Cellular localizationCell membrane and Secreted. Cell membrane.
- Information by UniProt
- Membrane mucin MUC17 antibody
- MUC-17 antibody
- MUC-3 antibody
ab122184 has been referenced in 3 publications.
- Sun WW et al. Nanoarchitecture and dynamics of the mouse enteric glycocalyx examined by freeze-etching electron tomography and intravital microscopy. Commun Biol 3:5 (2020). PubMed: 31925335
- Li W et al. The Prognosis Value of PIWIL1 and PIWIL2 Expression in Pancreatic Cancer. J Clin Med 8:N/A (2019). PubMed: 31443431
- Yang CW et al. Genetic variations of MUC17 are associated with endometriosis development and related infertility. BMC Med Genet 16:60 (2015). IHC . PubMed: 26285705