Product nameAnti-MUC2 antibody
See all MUC2 primary antibodies
DescriptionRabbit polyclonal to MUC2
Tested applicationsSuitable for: IHC-P, IHC-Fr, ICCmore details
Species reactivityReacts with: Human
Predicted to work with: RatDoes not react with: Mouse
Synthetic MUC2 peptide (Human) 23 amino acids long.
- Human colon carcinoma; LS 174 T colon cancer cell line.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.05% Sodium azide
Constituents: 1% BSA, 1.16% Sodium chloride, 0.0268% PBS
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab76774 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|IHC-Fr||1/50 - 1/100.|
|ICC||Use at an assay dependent concentration.|
FunctionCoats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
Tissue specificityColon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Sequence similaritiesContains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 TIL (trypsin inhibitory-like) domain.
Contains 2 VWFC domains.
Contains 4 VWFD domains.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
Cellular localizationSecreted. In the intestine, secreted into the inner and outer mucus layers.
- Information by UniProt
- Intestinal mucin 2 antibody
- Intestinal mucin-2 antibody
- MLP antibody
This product has been referenced in:
- Dai F et al. Expression of inositol-requiring enzyme 1ß is downregulated in azoxymethane/dextran sulfate sodium-induced mouse colonic tumors. Exp Ther Med 17:3181-3188 (2019). Read more (PubMed: 30936991) »
- Li JM et al. Dietary fructose-induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short-chain fatty acids. Microbiome 7:98 (2019). Read more (PubMed: 31255176) »