Anti-MUC2 antibody [SPM513], prediluted (ab52130)

Overview

  • Product name
    Anti-MUC2 antibody [SPM513], prediluted
    See all MUC2 primary antibodies
  • Description
    Mouse monoclonal [SPM513] to MUC2, prediluted
  • Host species
    Mouse
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Positive control
    • IHC: Human small intestine, colon, colon adenocarcinoma, prostate adenocarcinoma and stomach adenocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab52130 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: Ready-to-use for 30 min at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
    • Tissue specificity
      Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
    • Sequence similarities
      Contains 1 CTCK (C-terminal cystine knot-like) domain.
      Contains 1 TIL (trypsin inhibitory-like) domain.
      Contains 2 VWFC domains.
      Contains 4 VWFD domains.
    • Post-translational
      modifications
      O-glycosylated.
      May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
      At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
    • Cellular localization
      Secreted. In the intestine, secreted into the inner and outer mucus layers.
    • Information by UniProt
    • Database links
    • Alternative names
      • Intestinal mucin 2 antibody
      • Intestinal mucin-2 antibody
      • MLP antibody
      • MUC 2 antibody
      • MUC-2 antibody
      • Muc2 antibody
      • MUC2_HUMAN antibody
      • Mucin 2 antibody
      • Mucin 2 intestinal antibody
      • Mucin 2 intestinal/tracheal antibody
      • Mucin 2 oligomeric mucus/gel forming antibody
      • Mucin 2 precursor antibody
      • Mucin 2 tracheal antibody
      • Mucin like protein antibody
      • Mucin-2 antibody
      • Mucin2 antibody
      • SMUC antibody
      see all

    Images

    • Formalin-fixed, paraffin-embedded human small intestine tissue stained for MUC2 using ab52130 in immunohistochemical analysis.

    • Formalin-fixed, paraffin-embedded human colon tissue stained for MUC2 using ab52130 in immunohistochemical analysis.

    • Formalin-fixed, paraffin-embedded human colon adenocarcinoma tissue stained for MUC2 using ab52130 in immunohistochemical analysis.

    • Formalin-fixed, paraffin-embedded humanprostate adenocarcinoma tissue stained for MUC2 using ab52130 in immunohistochemical analysis.

    • Formalin-fixed, paraffin-embedded human stomach adenocarcinoma tissue stained for MUC2 using ab52130 in immunohistochemical analysis.

    References

    ab52130 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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