Overview

  • Product name

    Anti-Multicilin antibody
  • Description

    Rabbit polyclonal to Multicilin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Multicilin aa 3-110.
    Sequence:

    ACGGGAAGRRAFDSICPNRMLALPGRALLCKPGKPERKFAPPRKFFPGCT GGSPVSVYEDPPDAEPTALPALTTIDLQDLADCSSLLGSDAPPGGDLAAS QNHSHQTE


    Database link: D6RGH6

  • Positive control

    • IHC-P: Human prostate cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab222845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex (By similarity). Plays a role in mitotic cell cycle progression by promoting cell cycle exit.
  • Sequence similarities

    Belongs to the geminin family.
  • Developmental stage

    Probable target of the anaphase promoting complex/cyclosome (APC/C) which regulates its level in the cell during the mitotic cell cycle. Highly expressed during interphase and early mitosis. Expression decreases during anaphase to become undetectable during telophase and cytokinesis.
  • Cellular localization

    Nucleus. Excluded from the nucleolus.
  • Information by UniProt
  • Database links

  • Alternative names

    • IDAS antibody
    • Mci antibody
    • MCI_HUMAN antibody
    • Multicilin antibody
    • Protein Idas antibody
    see all

Images

  • Paraffin embedded human prostate cancer tissue stained for Multicilin with ab222845 at a 1/100 dilution.

References

ab222845 has not yet been referenced specifically in any publications.

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