Recombinant
RabMAb

Recombinant Anti-MUM1 antibody [SP114], prediluted (ab228154)

Overview

  • Product name

    Anti-MUM1 antibody [SP114], prediluted
    See all MUM1 primary antibodies
  • Description

    Rabbit monoclonal [SP114] to MUM1, prediluted
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Cow, Dog
  • Immunogen

    Synthetic peptide within Human MUM1 aa 100 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: Q15306

  • Positive control

    • IHC-P: Human Hodgkin's lymphoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab228154 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1.

Perform heat mediated antigen retrieval with 10 mM EDTA buffer before commencing with IHC staining protocol.

Ready to use.

Primary antibody incubation for 30 minutes at room temperature.

Target

  • Function

    Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
  • Tissue specificity

    Lymphoid cells.
  • Involvement in disease

    Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.
  • Sequence similarities

    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Interferon regulatory factor 4 antibody
    • IRF 4 antibody
    • IRF-4 antibody
    • Irf4 antibody
    • IRF4_HUMAN antibody
    • LSIRF antibody
    • Lymphocyte specific interferon regulatory factor antibody
    • Lymphocyte specific IRF antibody
    • Lymphocyte-specific interferon regulatory factor antibody
    • Multiple myeloma oncogene 1 antibody
    • MUM 1 antibody
    • MUM1 antibody
    • NF EM5 antibody
    • NF-EM5 antibody
    • NFEM5 antibody
    • PU.1 interaction partner antibody
    • Sfpi1/PU.1 interaction partner antibody
    • Transcriptional activator PIP antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human Hodgkin's lymphoma tissue stained for MUM1 using ab228154 in immunohistochemical analysis.

References

ab228154 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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