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Hello, I talked with a rep at the ASCB conference in San Francisco this past week and discussed your new Munc13-4 Ab (ab15723). However, I am interested in using this in mice. Do you have any suggestions about the likelyhood that this Ab would be a good candidate. I also would like to know if you would be willing to give us a sample to try. We are close to finishing a Munc13-4 conditional knock-out and will be using a large quantity of this antibody in the years to come if it is successful. Thanks for your help.
Asked on Dec 15 2005
Thank you for your enquiry. Unfortunately, in my opinion, this antibody would probably not cross-react mouse. I did an alignment of the immunogen with the mouse sequence, and got only 58% homology. The results are below: KQASQHALRPAP Immunogen RQRAKQASQHAP Mouse sequence :* :::* : ** This is our only Munc13-4 antibody, so I am unable to make a suggestion as to a different antibody that would be appropriate. You may wish to check the World's Antibody Gateway link on our search results page to search through 249 other companies to see if you can find an antibody that would work for you. I'm glad you got to meet our staff at the ASCB. Best of luck in your research! I hope this information helps, please do not hesitate to contact us if you need any more advice or information.
Answered on Dec 15 2005