Key features and details
- Rabbit polyclonal to Munc13-3
- Suitable for: IHC-P, ICC/IF
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Munc13-3 antibody
DescriptionRabbit polyclonal to Munc13-3
Tested applicationsSuitable for: IHC-P, ICC/IFmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Recombinant fragment corresponding to Human Munc13-3 aa 414-645.
RERKEKGIPSSQTYESMAIKLSTPEPKIKKNNWQSPDDSDEDLESDLNRN SYAVLSKSELLTKGSTSKPSSKSHSARSKNKTANSSRISNKSDYDKISSQ LPESDILEKQTTTHYADATPLWHSQSDFFTAKLSRSESDFSKLCQSYSED FSENQFFTRTNGSSLLSSSDRELWQRKQEGTATLYDSPKDQHLNGGVQGI QGQTETENTETVDSGMSNGMVCASGDRSHYSD
Database link: Q8NB66
- IHC-P: Human testis tissue. ICC/IF: HeLa cells.
Previously labelled as UNC13C.
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Constituents: 50% Glycerol (glycerin, glycerine), PBS, 0.03% Proclin 300
Concentration information loading...
PurityProtein G purified
Purification notesPurity >95%.
Our Abpromise guarantee covers the use of ab234798 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
|ICC/IF||1/50 - 1/200.|
FunctionProbably plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Probably is involved in neurotransmitter release.
Tissue specificityExclusively expressed in brain.
Sequence similaritiesBelongs to the unc-13 family.
Contains 2 C2 domains.
Contains 1 MHD1 (MUNC13 homology domain 1) domain.
Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Contains 1 phorbol-ester/DAG-type zinc finger.
DomainThe C2 domains are not involved in calcium-dependent phospholipid binding.
Cellular localizationCytoplasm. Membrane. Cell junction > synapse > presynaptic cell membrane. Localized to presynaptic structures.
- Information by UniProt
- DKFZp547H074 antibody
- Munc13 3 antibody
- Munc13-3 antibody
Paraffin-embedded human testis tissue stained for Munc13-3 using ab234798 at 1/100 dilution in immunohistochemical analysis.
HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for Munc13-3 (green) using ab234798 at 1/100 dilution in ICC/IF, followed by Alexa Fluor® 488 conjugated Goat Anti-Rabbit IgG (H+L).
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab234798 has not yet been referenced specifically in any publications.