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Rabbit monoclonal [EPR4849] to Munc18-1
ICC/IF more details Unsuitable for:
Flow Cyt or IHC-P
Mouse, Rat, Human
Synthetic peptide within Human Munc18-1 aa 150-250. The exact sequence is proprietary.
SH SY5Y and Human fetal brain lysates; SH SY5Y cells.
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Preservative: 0.05% Sodium azide Constituents: 0.1% BSA, 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
1/10 - 1/100.
1/100 - 1/250.
Is unsuitable for Flow Cyt or IHC-P.
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Brain and spinal cord. Highly enriched in axons.
Involvement in disease
Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
Belongs to the STXBP/unc-18/SEC1 family.
Information by UniProt
Munc 18 1 antibody
Munc 18a antibody
Western blot - Anti-Munc18-1 antibody [EPR4849] (ab109023)
All lanes : Anti-Munc18-1 antibody [EPR4849] (ab109023) at 1/1000 dilution Lane 1 : SH SY5Y cell lysate Lane 2 : Human fetal brain lysate Lysates/proteins at 10 µg per lane. Predicted band size: 68 kDa
Immunocytochemistry/ Immunofluorescence - Anti-Munc18-1 antibody [EPR4849] (ab109023)
ab109023 at 1/100 dilution staining Munc18 in SH SY5Y cells by Immunofluorescence.
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"