Overview

  • Product name

    Anti-Munc18-1 (phospho S313) antibody
    See all Munc18-1 primary antibodies
  • Description

    Rabbit polyclonal to Munc18-1 (phospho S313)
  • Host species

    Rabbit
  • Specificity

    ab138687 detects endogenous levels of Munc18 only when phosphorylated at S313.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: African green monkey
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Munc18-1 aa 307-319 (internal sequence) (phospho S313).
    Sequence:

    Human sequence

  • Positive control

    • COS7 cell extracts, treated with PMA (125ng/ml for 30mins).

Properties

Applications

Our Abpromise guarantee covers the use of ab138687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 68 kDa.

Target

  • Function

    May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
  • Tissue specificity

    Brain and spinal cord. Highly enriched in axons.
  • Involvement in disease

    Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
  • Sequence similarities

    Belongs to the STXBP/unc-18/SEC1 family.
  • Cellular localization

    Cytoplasm. Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ37475 antibody
    • Munc 18 1 antibody
    • Munc 18a antibody
    • MUNC18 1 antibody
    • N-Sec1 antibody
    • Neuronal SEC1 antibody
    • NSec1 antibody
    • p67 antibody
    • Protein unc-18 homolog 1 antibody
    • Protein unc-18 homolog A antibody
    • Rb sec1 antibody
    • RBSEC1 antibody
    • STXB1_HUMAN antibody
    • STXBP1 antibody
    • Syntaxin binding protein 1 antibody
    • Syntaxin-binding protein 1 antibody
    • Unc 18 homolog antibody
    • Unc 18A antibody
    • Unc-18A antibody
    • Unc18 1 antibody
    • UNC18 antibody
    • Unc18-1 antibody
    see all

Images

  • Anti-Munc18-1 (phospho S313) antibody (ab138687) at 1/500 dilution + COS7 cell extract, treated with PMA (125ng/ml for 30 mins) at 30 µg

    Predicted band size: 68 kDa

References

This product has been referenced in:

  • Simó A  et al. BDNF-TrkB Signaling Coupled to nPKCe and cPKCßI Modulate the Phosphorylation of the Exocytotic Protein Munc18-1 During Synaptic Activity at the Neuromuscular Junction. Front Mol Neurosci 11:207 (2018). Read more (PubMed: 29946239) »
See 1 Publication for this product

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