Key features and details
- Rabbit polyclonal to Munc18-2 - C-terminal
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Munc18-2 antibody - C-terminal
See all Munc18-2 primary antibodies
DescriptionRabbit polyclonal to Munc18-2 - C-terminal
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Fusion protein within Human Munc18-2 (C terminal). The exact sequence is proprietary. Fusion protein corresponding to residues near the C terminal of human Munc18-2 Isoform 2 (BC002869). The protein fusion partner is GST. .
Database link: Q15833-2
- HeLa and A549 whole cell lysate; Human liver cancer tissue lysate; Human lung cancer tissue
This product was previously labelled as STXBP2
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197798 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/100.|
|WB||1/200 - 1/1000. Predicted molecular weight: 66 kDa.|
FunctionInvolved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Tissue specificityPlacenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
Involvement in diseaseDefects in STXBP2 are the cause of hemophagocytic lymphohistiocytosis familial type 5 (FHL5) [MIM:613101]. FHL5 is rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Sequence similaritiesBelongs to the STXBP/unc-18/SEC1 family.
- Information by UniProt
- FHL5 antibody
- Hunc18b antibody
- MUNC18 2 antibody
All lanes : Anti-Munc18-2 antibody - C-terminal (ab197798) at 1/200 dilution
Lane 1 : A549 whole cell lysate
Lane 2 : Human liver cancer tissue lysate
Lane 3 : HeLa whole cell lysate
Lysates/proteins at 50 µg per lane.
Predicted band size: 66 kDa
Exposure time: 40 seconds
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue, labeling Munc18-2 with ab197798 at 1/20 dilution.
ab197798 has not yet been referenced specifically in any publications.