Overview

  • Product name

    Muristerone A, EcR agonist
  • Description

    Ecdysone receptor (EcR) agonist. Ecdysone analog.
  • Biological description

    Ecdysone receptor (EcR) agonist. Ecdysone (ab142425) analog. Potent ecdysone-inducible gene expression inducer. Stimulates Bcl-XL mRNA transcription. Inhibits TRAIL- and hFasL-induced apoptosis. Induces NGF release from fibroblasts.
  • Purity

    > 95%
  • CAS Number

    38778-30-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,3R,5S,9R,10R,11R,13R,14S,17S)-17-[(2R,3R)-2,3-Dihydroxy-6-methylheptan-2-yl]-2,3,5,11,14-pentahydroxy-10,13-dimethyl-1,2,3,4,9,11,12,15,16,17-decahydrocyclopenta[a]phenanthren-6-one
  • Molecular weight

    496.63
  • Molecular formula

    C27H44O8
  • PubChem identifier

    122217
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC[C@H]([C@@](C)([C@H]1CC[C@@]2([C@@]1(C[C@H]([C@H]3C2=CC(=O)[C@]4([C@@]3(C[C@@H]([C@@H](C4)O)O)C)O)O)C)O)O)O
  • Source

    Ipomoea hederacea

  • Research areas

References

This product has been referenced in:

  • Tohidi-Esfahani D  et al. Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest Manag Sci 67:1457-67 (2011). Read more (PubMed: 21594962) »
  • Patrick CW  et al. Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering. Tissue Eng 7:303-11 (2001). Read more (PubMed: 11429150) »
  • Constantino S  et al. The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells. Eur Cytokine Netw 12:365-7 (0). Read more (PubMed: 11399528) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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