Overview

  • Product name

    Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody
    See all Muscarinic Acetylcholine Receptor 1/CHRM1 primary antibodies
  • Description

    Goat polyclonal to Muscarinic Acetylcholine Receptor 1/CHRM1
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog, Pig, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human Muscarinic Acetylcholine Receptor 1/CHRM1 aa 438-453 (C terminal).
    Sequence:

    C-DKRRWRKIPKRPGSVH


    Database link: NP_000729.2

  • Positive control

    • Human brain lysate.
  • General notes

     This product was previously labelled as Muscarinic Acetylcholine Receptor 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab77098 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 51 kDa.Can be blocked with Human Muscarinic Acetylcholine Receptor 1/CHRM1 peptide (ab256411).

Target

  • Relevance

    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. Muscarinic receptors are so called as they are more sensitive to the effects of the alkaloid muscarine, rather than nicotine.
  • Cellular localization

    Cell Membrane; multi-pass membrane protein
  • Database links

  • Alternative names

    • AChR antibody
    • Cholinergic receptor muscarinic 1 antibody
    • CHRM1 antibody
    • HM1 antibody
    • M1 antibody
    • Muscarinic acetylcholine receptor M1 antibody
    see all

Images

  • Anti-Muscarinic Acetylcholine Receptor 1/CHRM1 antibody (ab77098) at 0.300000011920929 µg/ml + human brain lysate (in RIPA buffer) at 35 µg

    Predicted band size: 51 kDa
    Observed band size: 48 kDa
    why is the actual band size different from the predicted?

References

This product has been referenced in:

  • Winder M  et al. Autonomic Receptor-mediated Regulation of Production and Release of Nitric Oxide in Normal and Malignant Human Urothelial Cells. Basic Clin Pharmacol Toxicol 121:257-265 (2017). Read more (PubMed: 28437032) »
See 1 Publication for this product

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