Key features and details
- Rabbit polyclonal to Muscarinic Acetylcholine Receptor 2/CM2
- Suitable for: WB, ICC/IF, ELISA
- Reacts with: Rat
- Isotype: IgG
Product nameAnti-Muscarinic Acetylcholine Receptor 2/CM2 antibody
See all Muscarinic Acetylcholine Receptor 2/CM2 primary antibodies
DescriptionRabbit polyclonal to Muscarinic Acetylcholine Receptor 2/CM2
SpecificityM2 Muscarinic Receptor (457-466): 100% M2 Muscarinic Receptor: 50% No cross reactivity with M1, M3, M4 and M5 Muscarinic Receptors.
Tested applicationsSuitable for: WB, ICC/IF, ELISAmore details
Species reactivityReacts with: Rat
Synthetic peptide corresponding to Rat Muscarinic Acetylcholine Receptor 2/CM2 (C terminal).
- PLP fixed rat brain section; whole rat brain homogenate.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Concentration information loading...
Our Abpromise guarantee covers the use of ab41168 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: 1/5000. Fix with PLP.
WB: 1/1000. Predicted molecular weight: 52 kDa.
With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionThe muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Involvement in diseaseGenetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
Cellular localizationCell membrane. Cell junction > synapse > postsynaptic cell membrane.
- Information by UniProt
- 7TM receptor antibody
- Acetylcholine receptor, muscarinic, 2 antibody
- AChR antibody
ab41168 has not yet been referenced specifically in any publications.