• Product name

  • Description

    Rabbit polyclonal to MUSK
  • Host species

  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Does not react with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human MUSK aa 300-400 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab102603)

  • Positive control

    • This antibody gave a positive signal in Human and Mouse Skeletal Muscle Tissue Lysates.



Our Abpromise guarantee covers the use of ab92950 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 105 kDa (predicted molecular weight: 97 kDa).


  • Function

    Receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
  • Involvement in disease

    Defects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 FZ (frizzled) domain.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Post-translational

    Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • CMS9 antibody
    • FADS antibody
    • MDK 4 antibody
    • MDK4 antibody
    • MGC126323 antibody
    • MGC126324 antibody
    • Muscle antibody
    • Muscle associated receptor tyrosine kinase antibody
    • Muscle skeletal receptor tyrosine kinase antibody
    • Muscle skeletal receptor tyrosine protein kinase antibody
    • Muscle specific kinase receptor antibody
    • Muscle specific tyrosine kinase receptor antibody
    • Muscle specific tyrosine protein kinase receptor antibody
    • Muscle-specific kinase receptor antibody
    • Muscle-specific tyrosine-protein kinase receptor antibody
    • MuSK antibody
    • MUSK_HUMAN antibody
    • Neural fold somite kinase 1 antibody
    • Neural fold somite kinase 2 antibody
    • Neural fold somite kinase 3 antibody
    • Neural fold somite kinase1 antibody
    • Neural fold somite kinase2 antibody
    • Neural fold somite kinase3 antibody
    • Nsk 1 antibody
    • Nsk 2 antibody
    • Nsk 3 antibody
    • Nsk1 antibody
    • Nsk2 antibody
    • Nsk3 antibody
    • Receptor tyrosine kinase MuSK antibody
    • Skeletal muscle receptor tyrosine kinase antibody
    • skeletal receptor tyrosine-protein kinase antibody
    see all


  • All lanes : Anti-MUSK antibody (ab92950) at 1 µg/ml

    Lane 1 : Human skeletal muscle tissue lysate - total protein (ab29330)
    Lane 2 : Skeletal Muscle (Mouse) Tissue Lysate

    Lysates/proteins at 10 µg per lane.

    All lanes : Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

    Developed using the ECL technique.

    Performed under reducing conditions.

    Predicted band size: 97 kDa
    Observed band size: 105 kDa
    why is the actual band size different from the predicted?
    Additional bands at: 65 kDa, 80 kDa. We are unsure as to the identity of these extra bands.

    Exposure time: 2 minutes

    MUSK protein sequence contains two potential glycosylation sites (SwissProt Data), which may explain the migration of the band at a higher molecular weight than predicted.


This product has been referenced in:

  • Kelly NA  et al. Effects of aging and Parkinson's disease on motor unit remodeling: influence of resistance exercise training. J Appl Physiol (1985) 124:888-898 (2018). Read more (PubMed: 29357501) »
  • Logan CV  et al. Congenital Myasthenic Syndrome Type 19 Is Caused by Mutations in COL13A1, Encoding the Atypical Non-fibrillar Collagen Type XIII a1 Chain. Am J Hum Genet 97:878-85 (2015). Read more (PubMed: 26626625) »
See all 2 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

This product is known to not work in this application or species.
Western blot
Rat Cell lysate - whole cell (HEK293 cells transfected with rat MuSK)
Loading amount
30 µg
HEK293 cells transfected with rat MuSK
Gel Running Conditions
Reduced Denaturing (7,5% polyacrylamide)
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

Abcam user community

Verified customer

Submitted Sep 06 2012


Code de remise : ********
Date d’expiration : JJ MM AAAA

Je suis ravi que vous souhaitiez participer à notre offre et tester ab92950 chez le rat (80% d'homologie entre l'immunogène et la protéine de rat, voir fichier pdfjoint).
Le code promotionnel correspondant est *******, il est valable 4 mois et pour la commande d’un autre anticorps primaire gratuit.

Vous devez dans un premier temps soumettre une Abreview avec vos résultats chez le rat en notant ce code dans la section « Additional notes ». Ce code sera ainsi activé et vous pourrez par la suite contacter notre service clientèle par téléphone pour passer votre prochaine commande, en vous munissant des informations suivantes : code de réduction, numéro de commande de ab92950.

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