Product nameAnti-MUSK antibody - N-terminal
See all MUSK primary antibodies
DescriptionRabbit polyclonal to MUSK - N-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow
Recombinant fragment within Human MUSK (N terminal). The exact sequence is proprietary.
Database link: O15146
- WB: NT2/D1 whole cell lysate. IHC-P: Human breast cancer tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab228488 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 97 kDa.|
|IHC-P||1/100 - 1/1000.|
FunctionReceptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
Involvement in diseaseDefects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family.
Contains 1 FZ (frizzled) domain.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
modificationsUbiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
- Information by UniProt
- CMS9 antibody
- FADS antibody
- MDK 4 antibody
Anti-MUSK antibody - N-terminal (ab228488) at 1/1000 dilution + NT2/D1 (human embryonal testis carcinoma cell line) whole cell lysate
HRP-conjugated anti-rabbit IgG antibody
Predicted band size: 97 kDa
7.5% SDS PAGE
Paraffin-embedded human breast cancer tissue stained for MUSK using ab228488 at 1/250 dilution in immunohistochemical analysis.
ab228488 has not yet been referenced specifically in any publications.