Key features and details
- Rabbit polyclonal to MUSK (phospho Y755)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-MUSK (phospho Y755) antibody
See all MUSK primary antibodies
DescriptionRabbit polyclonal to MUSK (phospho Y755)
Specificityab192583 detects endogenous levels of MUSK only when phosphorylated at tyrosine 755.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide corresponding to Human MUSK (phospho Y755).
Database link: O15146
- Jurkat whole cell lysate (ab7899)
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride
PBS is without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab192583 was purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatography using non-phosphopeptide.
Our Abpromise guarantee covers the use of ab192583 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 97 kDa.|
FunctionReceptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization.
Involvement in diseaseDefects in MUSK is a cause of congenital myasthenic syndrome with acetylcholine receptor deficiency (CMS-ACHRD) [MIM:608931]. A post-synaptic congenital myasthenic syndrome. Mutations underlying AChR deficiency cause a 'loss of function' and show recessive inheritance. Note=MUSK mutations lead to decreased agrin-dependent AChR aggregation, a critical step in the formation of the neuromuscular junction.
Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family.
Contains 1 FZ (frizzled) domain.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.
modificationsUbiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation.
- Information by UniProt
- CMS9 antibody
- FADS antibody
- MDK 4 antibody
ab192583 has been referenced in 1 publication.
- Aare S et al. Failed reinnervation in aging skeletal muscle. Skelet Muscle 6:29 (2016). PubMed: 27588166