Overview

  • Product name
  • Description
    Rabbit polyclonal to MVK
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 163-396 of Human MVK (UniProt ID: Q03426).

  • Positive control
    • 293T, A431, HepG2, Raji whole cell lysate and A549 xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab154515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 42 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Alternatively Tris-EDTA buffer (pH8.0) may be used.

Target

  • Function
    May be a regulatory site in cholesterol biosynthetic pathway.
  • Pathway
    Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • Involvement in disease
    Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • Sequence similarities
    Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • Cellular localization
    Cytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

Images

  • Anti-MVK antibody (ab154515) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size: 42 kDa



    10% SDS PAGE
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded A549 xenograft labeling MVK with ab154515 at 1/500.

References

ab154515 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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