• Product name

    Anti-MVK antibody [EPR6507]
    See all MVK primary antibodies
  • Description

    Rabbit monoclonal [EPR6507] to MVK
  • Host species

  • Tested applications

    Suitable for: WB, IP, Flow Cytmore details
    Unsuitable for: ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MVK aa 300-400. The exact sequence is proprietary.

  • Positive control

    • Permeabilized HepG2 cells; Human fetal liver, HepG2, Jurkat and Caco-2 cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab126619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
IP 1/10 - 1/100.
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


  • Application notes
    Is unsuitable for ICC/IF or IHC-P.
  • Target

    • Function

      May be a regulatory site in cholesterol biosynthetic pathway.
    • Pathway

      Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
    • Involvement in disease

      Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
      Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
    • Sequence similarities

      Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
    • Cellular localization

      Cytoplasm. Peroxisome.
    • Information by UniProt
    • Database links

    • Alternative names

      • FLJ96772 antibody
      • KIME_HUMAN antibody
      • LH receptor mRNA binding protein antibody
      • LRBP antibody
      • Mevalonate kinase 1 antibody
      • Mevalonate kinase antibody
      • Mevalonic aciduria antibody
      • MK antibody
      • mvk antibody
      • MVLK antibody
      • POROK3 antibody
      see all


    • All lanes : Anti-MVK antibody [EPR6507] (ab126619) at 1/1000 dilution

      Lane 1 : HepG2 cell lysate
      Lane 2 : Jurkat cell lysate
      Lane 3 : Caco-2 cell lysate
      Lane 4 : Human fetal liver lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 42 kDa
      Observed band size: 42 kDa

    • ab126619, at a 1/10 dilution, positively staining MVK in permeabilized HepG2 cells (red). A Rabbit IgG was used as negative control (green).
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD


    ab126619 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab126619.
    Please use the links above to contact us or submit feedback about this product.

    For licensing inquiries, please contact partnerships@abcam.com

    Sign up