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Cardiovascular Lipids / Lipoproteins Lipid Metabolism Cholesterol Metabolism
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RecombinantRabMAb

Recombinant Anti-MVK antibody [EPR6507] (ab126619)

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Western blot - Anti-MVK antibody [EPR6507] (ab126619)
  • Flow Cytometry - Anti-MVK antibody [EPR6507] (ab126619)
  • OI-RD Scanning - Anti-MVK antibody [EPR6507] (ab126619)
  • Anti-MVK antibody [EPR6507] (ab126619)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR6507] to MVK
  • Suitable for: WB, Flow Cyt
  • Reacts with: Human

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-MVK antibody [EPR6507]
    See all MVK primary antibodies
  • Description

    Rabbit monoclonal [EPR6507] to MVK
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MVK aa 300-400. The exact sequence is proprietary.

  • Positive control

    • Permeabilized HepG2 cells; Human fetal liver, HepG2, Jurkat and Caco-2 cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Dissociation constant (KD)

    KD = 1.88 x 10 -10 M
    Learn more about KD
  • Storage buffer

    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant
  • Concentration information loading...
  • Purity

    Tissue culture supernatant
  • Clonality

    Monoclonal
  • Clone number

    EPR6507
  • Isotype

    IgG
  • Research areas

    • Cardiovascular
    • Lipids / Lipoproteins
    • Lipid Metabolism
    • Cholesterol Metabolism
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Cancer
    • Cancer Metabolism
    • Metabolic signaling pathway
    • Metabolism of lipids and lipoproteins
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Cholesterol Metabolism
    • Metabolism
    • Types of disease
    • Cancer

Associated products

  • Alternative Versions

    • Anti-MVK antibody [EPR6507] - BSA and Azide free (ab248129)
  • Isotype control

    • Rabbit IgG, monoclonal [EPR25A] - Isotype Control (ab172730)
  • Positive Controls

    • Hep G2 cytoplasmic extract lysate (ab14659)
    • Jurkat cytoplasmic extract lysate (ab14842)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab126619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
1/1000 - 1/10000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
Flow Cyt
1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

Notes
WB
1/1000 - 1/10000. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
Flow Cyt
1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

 

  • Application notes
    Is unsuitable for ICC/IF or IHC-P.
  • Target

    • Function

      May be a regulatory site in cholesterol biosynthetic pathway.
    • Pathway

      Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
    • Involvement in disease

      Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
      Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
    • Sequence similarities

      Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
    • Cellular localization

      Cytoplasm. Peroxisome.
    • Target information above from: UniProt accession Q03426 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 4598 Human
      • Omim: 251170 Human
      • SwissProt: Q03426 Human
      • Unigene: 130607 Human
      • Alternative names

        • FLJ96772 antibody
        • KIME_HUMAN antibody
        • LH receptor mRNA binding protein antibody
        • LRBP antibody
        • Mevalonate kinase 1 antibody
        • Mevalonate kinase antibody
        • Mevalonic aciduria antibody
        • MK antibody
        • mvk antibody
        • MVLK antibody
        • POROK3 antibody
        see all

      Images

      • Western blot - Anti-MVK antibody [EPR6507] (ab126619)
        Western blot - Anti-MVK antibody [EPR6507] (ab126619)
        All lanes : Anti-MVK antibody [EPR6507] (ab126619) at 1/1000 dilution

        Lane 1 : HepG2 cell lysate
        Lane 2 : Jurkat cell lysate
        Lane 3 : Caco-2 cell lysate
        Lane 4 : Human fetal liver lysate

        Lysates/proteins at 10 µg per lane.

        Secondary
        All lanes : Standard HRP labelled goat anti-rabbit at 1/2000 dilution

        Predicted band size: 42 kDa
        Observed band size: 42 kDa

      • Flow Cytometry - Anti-MVK antibody [EPR6507] (ab126619)
        Flow Cytometry - Anti-MVK antibody [EPR6507] (ab126619)
        ab126619, at a 1/10 dilution, positively staining MVK in permeabilized HepG2 cells (red). A Rabbit IgG was used as negative control (green).
      • OI-RD Scanning - Anti-MVK antibody [EPR6507] (ab126619)
        OI-RD Scanning - Anti-MVK antibody [EPR6507] (ab126619)
        Equilibrium disassociation constant (KD)
        Learn more about KD

        Click here to learn more about KD
      • Anti-MVK antibody [EPR6507] (ab126619)
        Anti-MVK antibody [EPR6507] (ab126619)

      Protocols

      • Western blot protocols
      • Flow cytometry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab126619? Please let us know so that we can cite the reference in this datasheet.

      ab126619 has not yet been referenced specifically in any publications.

      Customer reviews and Q&As

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