Product nameAnti-MVP antibody [LRP-56]
See all MVP primary antibodies
DescriptionMouse monoclonal [LRP-56] to MVP
Tested applicationsSuitable for: Flow Cyt, ICC, IHC-Fr, IHC-Pmore details
Species reactivityReacts with: Human
2R120 cell line derived by stepwise Doxorubicin exposure of the the SW-1573 non-small cell lung carcinoma cell line.
- Lung, Colon, kidney, bronchus or adrenal cortex (human tissue). Also in MDR cell lines such as GLC4/ADR, HT1080/DR4 & 2R120. Negative control antibody: Normal mouse serum
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: 1% BSA
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab3367 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC: Use at an assay dependent dilution.
IHC-Fr: Frozen tissues, cell lines, formalin-fixed/paraffin embedded tissues. 1/10 - 1/40. Pretreatment is not required. For optimal staining, the primary antibody should be incubated overnight at 4°C.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionRequired for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Tissue specificityPresent in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Sequence similaritiesContains 9 MVP (vault) repeats.
DomainMVP 3 mediates interaction with PTEN.
MVP 4 mediates interaction with PARP4.
modificationsPhosphorylated on Tyr residues after EGF stimulation.
Dephosphorylated by PTPN11.
Cellular localizationCytoplasm. Nucleus > nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment.
- Information by UniProt
- LRP antibody
- Lung resistance related protein antibody
- Lung resistance-related protein antibody
ab3367 has not yet been referenced specifically in any publications.