Recombinant
RabMAb

Recombinant Anti-MYBPC3 antibody [EPR3008(2)] - BSA and Azide free (ab203258)

Overview

  • Product name

    Anti-MYBPC3 antibody [EPR3008(2)] - BSA and Azide free
    See all MYBPC3 primary antibodies
  • Description

    Rabbit monoclonal [EPR3008(2)] to MYBPC3 - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human MYBPC3 aa 100-200. The exact sequence is proprietary.

  • Positive control

    • Human heart lysate
  • General notes

    ab203258 is the carrier-free version of ab108522 This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Ab203258 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Maxpar® is a trademark of Fluidigm Canada Inc.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab203258 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 141 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function

      Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
    • Involvement in disease

      Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similarities

      Belongs to the immunoglobulin superfamily. MyBP family.
      Contains 3 fibronectin type-III domains.
      Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • Post-translational
      modifications

      Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
    • Information by UniProt
    • Database links

    • Alternative names

      • C protein cardiac muscle isoform antibody
      • C-protein antibody
      • cardiac muscle isoform antibody
      • Cardiac MyBP C antibody
      • Cardiac MyBP-C antibody
      • Cardiac myosin binding protein C antibody
      • cardiac-type antibody
      • CMH4 antibody
      • FHC antibody
      • MYBP C antibody
      • MYBPC antibody
      • MYBPC3 antibody
      • Myosin binding protein C cardiac antibody
      • Myosin binding protein C cardiac-type antibody
      • Myosin-binding protein C antibody
      • myosin-binding protein C cardiac type antibody
      • MYPC3_HUMAN antibody
      see all

    References

    ab203258 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab203258.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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