Anti-Mycobacterium tuberculosis antibody (ab905)
Key features and details
- Rabbit polyclonal to Mycobacterium tuberculosis
- Suitable for: IHC-P
- Isotype: IgG
Overview
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Product name
Anti-Mycobacterium tuberculosis antibody
See all Mycobacterium tuberculosis primary antibodies -
Description
Rabbit polyclonal to Mycobacterium tuberculosis -
Host species
Rabbit -
Specificity
This antibody is reactive with other Mycobacteria species including: M. avium, M. phlei, and M. parafortuitum. This antibody has been reported not to be reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitides. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
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Immunogen
Purified Protein Derivative
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: PBS, Carrier protein
Da Vinci Green Diluent -
Concentration information loading...
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Purity
IgG fraction -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Antibody Diluent
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
1/100 - 1/200. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. ABC method.
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Notes |
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IHC-P
1/100 - 1/200. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. ABC method. |
Target
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Relevance
Mycobacterium tuberculosis is the most common cause of tuberculosis. Primary infection begins with inhalation of 1 to 10 aerosolised bacilli. The pathogenicity of the organism is determined by its ability to escape host immune responses as well as eliciting delayed hypersensitivity. Alveolar macrophages engulf the invading cells but are unable to mount an effective defense. Several virulence factors are responsible for this apparent failure; most notably in the mycobacterial cell wall are the cord factor, lipoarabinomannan, and the 65 kd heat shock protein or HSP65. The emergence of new strains of resistant Mycobacterium tuberculosis has created new interest in clinical diagnosis. Studies have shown immunohistochemical techniques to be superior to conventional special stains. Thus the demonstration of mycobacterial antigens are not only useful in establishing mycobacterial aetiology, but can also be used as an alternative method to the conventional Ziehl-Neelsen method. -
Alternative names
- M. tuberculosis antibody
Images
Protocols
References (16)
ab905 has been referenced in 16 publications.
- Krishnamoorthy G et al. FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity. Dis Model Mech 13:N/A (2020). PubMed: 32034005
- Chai Q et al. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nat Commun 10:1973 (2019). PubMed: 31036822
- Headley CA et al. Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation. Aging Cell 18:e12926 (2019). PubMed: 30834643
- Chouhan D et al. Mycobacterium abscessus infection in the stomach of patients with various gastric symptoms. PLoS Negl Trop Dis 13:e0007799 (2019). PubMed: 31682611
- Gautam US et al. Mycobacterium tuberculosis sensor kinase DosS modulates the autophagosome in a DosR-independent manner. Commun Biol 2:349 (2019). PubMed: 31552302