Key features and details
- Mouse monoclonal [2C7] to Myeloperoxidase (FITC)
- Suitable for: IHC-Fr, Flow Cyt
- Reacts with: Human
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
Product nameAnti-Myeloperoxidase antibody [2C7] (FITC)
See all Myeloperoxidase primary antibodies
DescriptionMouse monoclonal [2C7] to Myeloperoxidase (FITC)
ConjugationFITC. Ex: 493nm, Em: 528nm
Specificityab11729 recognises human myeloperoxidase.
Tested applicationsSuitable for: IHC-Fr, Flow Cytmore details
Species reactivityReacts with: Human
General notesThis product should be stored undiluted. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.40
Preservative: 0.09% Sodium azide
Constituents: PBS, 1% BSA
Concentration information loading...
PurityProtein G purified
Purification notesPurified IgG prepared by affinity chromatography.
Our Abpromise guarantee covers the use of ab11729 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||Use at an assay dependent concentration.|
|Flow Cyt||1/1 - 1/10.
Use 10 µl of the suggested working dilution to label 106 cells in 100 µl. This antibody may be used for the flow cytometric detection of myeloid cells following membrane permeablisation.
ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in diseaseDefects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
- Information by UniProt
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 18.104.22.168 antibody
ab11729 has been referenced in 6 publications.
- Xu K et al. Adenosine from a biologic source regulates neutrophil extracellular traps (NETs). J Leukoc Biol 105:1225-1234 (2019). PubMed: 30907983
- Nesmond S et al. Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid. Front Immunol 10:2107 (2019). PubMed: 31572359
- Bystrzycka W et al. Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release. Int J Mol Sci 18:N/A (2017). PubMed: 29292737
- Bystrzycka W et al. The effect of clindamycin and amoxicillin on neutrophil extracellular trap (NET) release. Cent Eur J Immunol 41:1-5 (2016). PubMed: 27095915
- Gavillet M et al. Flow cytometric assay for direct quantification of neutrophil extracellular traps in blood samples. Am J Hematol 90:1155-8 (2015). PubMed: 26347989
- Nyåkern M et al. Frequent elevation of Akt kinase phosphorylation in blood marrow and peripheral blood mononuclear cells from high-risk myelodysplastic syndrome patients. Leukemia 20:230-8 (2006). PubMed: 16341040