Key features and details
- Mouse monoclonal [2D4] to Myeloperoxidase
- Suitable for: ICC/IF
- Reacts with: Mouse, Rat
- Isotype: IgG1
Product nameAnti-Myeloperoxidase antibody [2D4]
See all Myeloperoxidase primary antibodies
DescriptionMouse monoclonal [2D4] to Myeloperoxidase
Tested applicationsSuitable for: ICC/IFmore details
Unsuitable for: IHC-P or WB
Species reactivityReacts with: Mouse, Rat
Full length native protein (purified) corresponding to Myeloperoxidase. Antigen used is purified natural MPO from mice
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSA
Concentration information loading...
PurityProtein G purified
Purification notesab90810 is provided as a 0.2 µm filtered solution.
Our Abpromise guarantee covers the use of ab90810 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionPart of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in diseaseDefects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
- Information by UniProt
- 84 kDa myeloperoxidase antibody
- 89 kDa myeloperoxidase antibody
- EC 220.127.116.11 antibody
ab90810 has been referenced in 10 publications.
- Xu D et al. Overproduced bone marrow neutrophils in collagen-induced arthritis are primed for NETosis: An ignored pathological cell involving inflammatory arthritis. Cell Prolif 53:e12824 (2020). PubMed: 32567730
- Jin R et al. IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia. Cell Death Discov 6:33 (2020). PubMed: 32377396
- Han XA et al. Necrostatin-1 Ameliorates Neutrophilic Inflammation in Asthma by Suppressing MLKL Phosphorylation to Inhibiting NETs Release. Front Immunol 11:666 (2020). PubMed: 32391007
- Wang N et al. Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection. Cell Death Discov 5:111 (2019). PubMed: 31285854
- Dang G et al. Extracellular Sphingomyelinase Rv0888 of Mycobacterium tuberculosis Contributes to Pathological Lung Injury of Mycobacterium smegmatis in Mice via Inducing Formation of Neutrophil Extracellular Traps. Front Immunol 9:677 (2018). PubMed: 29670633
- Gan T et al. TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase. Front Microbiol 9:3174 (2018). PubMed: 30622526
- Wang L et al. Hyperglycemia Induces Neutrophil Extracellular Traps Formation Through an NADPH Oxidase-Dependent Pathway in Diabetic Retinopathy. Front Immunol 9:3076 (2018). PubMed: 30671057
- Abdollahi M et al. Insulin treatment prevents wounding associated changes in tissue and circulating neutrophil MMP-9 and NGAL in diabetic rats. PLoS One 12:e0170951 (2017). ICC/IF ; Rat . PubMed: 28182694
- Jie H et al. Necrostatin-1 enhances the resolution of inflammation by specifically inducing neutrophil apoptosis. Oncotarget 7:19367-81 (2016). IHC . PubMed: 27027357
- Jhunjhunwala S et al. Neutrophil Responses to Sterile Implant Materials. PLoS One 10:e0137550 (2015). Mouse . PubMed: 26355958