Overview

  • Product name

  • Description

    Rabbit polyclonal to Myh14
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human Myh14 aa 654-668 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q7Z406

  • Positive control

    • IHC-P: Human small intestine tissue. WB: A431 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab230418 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.
WB 1/1000. Predicted molecular weight: 228 kDa.

Target

  • Function

    Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.
  • Tissue specificity

    High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes.
  • Involvement in disease

    Defects in MYH14 are the cause of deafness autosomal dominant type 4A (DFNA4A) [MIM:600652]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
    Defects in MYH14 are the cause of peripheral neuropathy, myopathy, hoarseness, and hearing loss (PNMHH) [MIM:614369]. PNMHH is a complex phenotype of progressive peripheral neuropathy and distal myopathy, with later onset of hoarseness and hearing loss. Affected individuals develop distal muscle weakness at a mean age of 10.6 years, followed by progressive atrophy of these muscles. The lower limbs are more severely affected than the upper limbs, and the muscle weakness first affects anterior leg muscles and later posterior leg muscles.
  • Sequence similarities

    Contains 1 IQ domain.
    Contains 1 myosin head-like domain.
  • Domain

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2400004E04Rik antibody
    • DFNA4 antibody
    • DKFZp667A1311 antibody
    • FLJ13881 antibody
    • FLJ43092 antibody
    • FP17425 antibody
    • II C antibody
    • KIAA2034 antibody
    • MHC16 antibody
    • Myh 14 antibody
    • MYH14 antibody
    • MYH14_HUMAN antibody
    • Myosin 14 antibody
    • Myosin antibody
    • Myosin heavy chain 14 antibody
    • Myosin heavy chain antibody
    • Myosin heavy chain non muscle IIc antibody
    • Myosin heavy polypeptide 14 antibody
    • Myosin-14 antibody
    • NMHC II C antibody
    • NMHC II-C antibody
    • Non muscle myosin heavy chain IIc antibody
    • non-muscle IIc antibody
    • Non-muscle myosin heavy chain IIc antibody
    • Nonmuscle myosin heavy chain II C antibody
    • OTTMUSP00000019210 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human small intestine tissue stained for Myh14 using ab230418 at 1/100 dilution in immunohistochemical analysis.

  • Anti-Myh14 antibody (ab230418) at 1/1000 dilution + A431 (human epidermoid carcinoma cell line) cell lysate at 35 µg

    Secondary
    Goat anti-rabbit IgG H&L (HRP) at 1/5000 dilution

    Predicted band size: 228 kDa

References

ab230418 has not yet been referenced specifically in any publications.

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