Product nameAnti-MYH/MUTYH antibody
See all MYH/MUTYH primary antibodies
DescriptionRabbit polyclonal to MYH/MUTYH
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human MYH/MUTYH (C terminal). (C terminal 300 amino acids with tag; BC003178).
Database link: Q9UIF7-3
- Human liver cancer and stomach cancer tissue lysates; Human lung cancer tissue.
This product was previously labelled as MYH
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Note: PBS without Mg2+ and Ca2+.
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab182759 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/5000. Predicted molecular weight: 59 kDa.|
|IHC-P||1/50 - 1/200.|
FunctionInvolved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Involvement in diseaseDefects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.
Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence similaritiesBelongs to the Nth/MutY family.
Contains 1 nudix hydrolase domain.
- Information by UniProt
- A/G specific adenine DNA glycosylase antibody
- A/G-specific adenine DNA glycosylase antibody
- Adenine DNA glycosylase antibody
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling MYH/MUTYH with ab182759 at 1/60 dilution (left panel). Right panel is treated with the immunogen.
All lanes : Anti-MYH/MUTYH antibody (ab182759) at 1/1000 dilution
Lane 1 : Human liver cancer tissue lysate
Lane 2 : Human stomach cancer tissue lysate
Lysates/proteins at 40 µg per lane.
All lanes : Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Developed using the ECL technique.
Predicted band size: 59 kDa
Exposure time: 1 minute
Gel: 8% SDS-PAGE
ab182759 has not yet been referenced specifically in any publications.