• Product name

  • Description

    Rabbit polyclonal to MYH/MUTYH
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human MYH/MUTYH (internal sequence). The exact sequence is proprietary.
    Database link: Q9UIF7

  • Positive control

    • WB: HeLa, HepG2 and NIH/3T3 whole cell lysates. ICC/IF: HeLa cells.
  • General notes

     This product was previously labelled as MYH



  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab228722 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 60 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.


  • Function

    Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
  • Involvement in disease

    Defects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.
    Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
  • Sequence similarities

    Belongs to the Nth/MutY family.
    Contains 1 nudix hydrolase domain.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • A/G specific adenine DNA glycosylase antibody
    • A/G-specific adenine DNA glycosylase antibody
    • Adenine DNA glycosylase antibody
    • CYP2C antibody
    • hMYH antibody
    • MGC4416 antibody
    • MutY (E. coli) homolog antibody
    • MutY homolog (E. coli) antibody
    • MutY homolog antibody
    • MutY, E. coli, homolog of antibody
    • Mutyh antibody
    • MUTYH_HUMAN antibody
    • MYH antibody
    • rMYH antibody
    see all


  • HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for MYH/MUTYH (green) using ab228722 at 1/500 dilution in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

    Blue: Hoechst 33342 staining.

  • All lanes : Anti-MYH/MUTYH antibody (ab228722) at 1/1000 dilution

    Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
    Lane 2 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate

    Lysates/proteins at 30 µg per lane.

    All lanes : HRP-conjugated anti-rabbit IgG

    Predicted band size: 60 kDa

    7.5% SDS-PAGE gel.

  • Anti-MYH/MUTYH antibody (ab228722) at 1/1000 dilution + NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate at 30 µg

    HRP-conjugated anti-rabbit IgG

    Predicted band size: 60 kDa

    7.5% SDS-PAGE gel.


ab228722 has not yet been referenced specifically in any publications.

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