Key features and details
- Goat polyclonal to MYH/MUTYH - C-terminal
- Suitable for: WB
- Reacts with: Mouse, Rat, Dog, Human, Monkey
- Isotype: IgG
Product nameAnti-MYH/MUTYH antibody - C-terminal
See all MYH/MUTYH primary antibodies
DescriptionGoat polyclonal to MYH/MUTYH - C-terminal
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Rat, Dog, Human, Monkey
- 293HEK cells transfected with cds plasmid (myc-his-Mutyh).
This product was previously labelled as MYH
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.05% Sodium azide
Constituents: 79% PBS, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab192462 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 60 kDa.|
FunctionInvolved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Involvement in diseaseDefects in MUTYH are a cause of familial adenomatous polyposis type 2 (FAP2) [MIM:608456]. A condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma.
Defects in MUTYH are a cause of gastric cancer (GASC) [MIM:613659]. A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Sequence similaritiesBelongs to the Nth/MutY family.
Contains 1 nudix hydrolase domain.
- Information by UniProt
- A/G specific adenine DNA glycosylase antibody
- A/G-specific adenine DNA glycosylase antibody
- Adenine DNA glycosylase antibody
ab192462 has not yet been referenced specifically in any publications.