Description

Associated products

Specifications

Our Abpromise guarantee covers the use of ab204866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form

    Lyophilised
  • Additional notes

    ab204866 (MYL12A peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab179508 (Active human DRAK1 full length protein)

    Previously labelled as MRCL3.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names

    • ML12A_HUMAN
    • MLC 2B
    • MLC-2B
    • MLCB
    • MRCL3
    • MYL12A
    • Myosin regulatory light chain 12A
    • Myosin regulatory light chain 2
    • Myosin regulatory light chain 2, nonsarcomeric
    • Myosin regulatory light chain MRCL3
    • Myosin regulatory light chain MRLC3
    • Myosin RLC
    • Myosin, light polypeptide, regulatory, non sarcomeric (20kD)
    • nonsarcomeric
    • RLC
    see all
  • Function

    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.
  • Sequence similarities

    Contains 3 EF-hand domains.
  • Post-translational
    modifications

    Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.
  • Information by UniProt

References

ab204866 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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