Overview

  • Product name

    Anti-MYLK2 antibody
  • Description

    Rabbit polyclonal to MYLK2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 270-551 of Human MYLK2 (Uniprot ID: Q9H1R3).

  • Positive control

    • MOLT4, Raji whole cell lysates
  • General notes

    Keep as a concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab155506 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 65 kDa.

Target

  • Function

    Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
  • Tissue specificity

    Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
  • Involvement in disease

    Defects in MYLK2 are a cause of familial hypertrophic cardiomyopathy (CMH) [MIM:192600]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization

    Cytoplasm. Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
  • Information by UniProt
  • Database links

  • Alternative names

    • KMLC antibody
    • MLCK antibody
    • MLCK, skeletal/cardiac antibody
    • MLCK2 antibody
    • MYLK 2 antibody
    • MYLK2 antibody
    • MYLK2_HUMAN antibody
    • Myosin light chain kinase 2 antibody
    • Myosin light chain kinase 2 skeletal muscle antibody
    • Myosin light chain kinase 2 skeletal/cardiac muscle antibody
    • MYOSIN LIGHT POLYPEPTIDE KINASE antibody
    • Myosin light polypeptide kinase, skeletal/cardiac antibody
    • Skeletal muscle myosin light chain kinase antibody
    • Skeletal myosin light chain kinase antibody
    • skeletal/cardiac muscle antibody
    • skMLCK antibody
    see all

Images

  • Anti-MYLK2 antibody (ab155506) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size: 65 kDa



    7.5% SDS PAGE

References

ab155506 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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