Key features and details
- Rabbit polyclonal to Myocilin
- Suitable for: IHC-P
- Reacts with: Mouse, Rat, Human, Monkey
- Isotype: IgG
Product nameAnti-Myocilin antibody
DescriptionRabbit polyclonal to Myocilin
SpecificityThe antibody does not cross react with any other protein in RPE cells.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human, Monkey
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferStabilization buffer containing preservatives.
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab41552 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionMay participate in the obstruction of fluid outflow in the trabecular meshwork.
Tissue specificityExpressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Expressed predominantly in the retina. In normal eyes, found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma.
Involvement in diseaseDefects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Sequence similaritiesContains 1 olfactomedin-like domain.
modificationsDifferent isoforms may arise by post-translational modifications.
Cellular localizationRough endoplasmic reticulum. Secreted. Cell projection > cilium. Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. Also secreted.
- Information by UniProt
- GLC1A antibody
- GPOA antibody
- JOAG antibody
ab41552 has been referenced in 4 publications.
- Fan Y et al. Effects of Salidroside on Trabecular Meshwork Cell Extracellular Matrix Expression and Mouse Intraocular Pressure. Invest Ophthalmol Vis Sci 60:2072-2082 (2019). PubMed: 31091314
- Huo R et al. RNA Sequencing Reveals the Activation of Wnt Signaling in Low Flow Rate Brain Arteriovenous Malformations. J Am Heart Assoc 8:e012746 (2019). PubMed: 31170876
- Faralli JA et al. Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone. PLoS One 13:e0192665 (2018). PubMed: 29499052
- Keller KE et al. Consensus recommendations for trabecular meshwork cell isolation, characterization and culture. Exp Eye Res 171:164-173 (2018). PubMed: 29526795