Anti-Myosin antibody [MAC 147] (ab51098)
Key features and details
- Rat monoclonal [MAC 147] to Myosin
- Reacts with: Drosophila melanogaster, Waterbug
- Isotype: IgG1
Overview
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Product name
Anti-Myosin antibody [MAC 147]
See all Myosin primary antibodies -
Description
Rat monoclonal [MAC 147] to Myosin -
Host species
Rat -
Specificity
Reacts with subfagment 2 of Lethocerus and Drosophila myosin -
Species reactivity
Reacts with: Drosophila melanogaster, Waterbug -
Immunogen
Flight muscle myosin purified from Lethocerus indicus (Waterbug)
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.
One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.
Learn more here.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
MAC 147 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
Muscle contraction. -
Sequence similarities
Contains 1 IQ domain.
Contains 1 myosin head-like domain. -
Domain
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2). -
Cellular localization
Cytoplasm > myofibril. Thick filaments of the myofibrils. - Information by UniProt
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Alternative names
- adult 1 antibody
- MYH1 antibody
- MYH1_HUMAN antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (8)
ab51098 has been referenced in 8 publications.
- Di Cara F et al. Distinct Roles for Peroxisomal Targeting Signal Receptors Pex5 and Pex7 in Drosophila. Genetics 211:141-149 (2019). PubMed: 30389805
- Hessinger C et al. The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections. Development 144:139-150 (2017). PubMed: 27913640
- Molnár I et al. DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila. PLoS Genet 10:e1004166 (2014). ICC/IF ; Drosophila melanogaster . PubMed: 24586196
- Tarver MR et al. Myosin Gene Expression and Protein Abundance in Different Castes of the Formosan Subterranean Termite (Coptotermes formosanus). Insects 3:1190-9 (2012). PubMed: 26466734
- Hsu CY & Chan YP Identification and Localization of Proteins Associated with Biomineralization in the Iron Deposition Vesicles of Honeybees (Apis mellifera). PLoS One 6:e19088 (2011). WB ; Other species . PubMed: 21541330
- Deng H et al. Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos. Mol Biol Cell 21:3304-16 (2010). ICC/IF ; Drosophila melanogaster . PubMed: 20685961
- Qiu F et al. Myofilin, a protein in the thick filaments of insect muscle. J Cell Sci 118:1527-36 (2005). PubMed: 15769842
- Fyrberg E et al. Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities. J Mol Biol 216:657-75 (1990). PubMed: 2124273