Overview

  • Product name

    Anti-Myosin light chain 3 antibody
    See all Myosin light chain 3 primary antibodies
  • Description

    Rabbit polyclonal to Myosin light chain 3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken, Cow
  • Immunogen

    Recombinant fragment corresponding to a region within amino acids 1-195 of Human Myosin light chain 3 (NP_000249).

  • Positive control

    • MOLT4 and Mouse heart whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab137767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 21 kDa.

Target

  • Function

    Regulatory light chain of myosin. Does not bind calcium.
  • Involvement in disease

    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.
    Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.
  • Sequence similarities

    Contains 3 EF-hand domains.
  • Post-translational
    modifications

    The N-terminus is blocked.
    N-terminus is methylated by METTL11A/NTM1.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cardiac myosin light chain 1 antibody
    • CMH8 antibody
    • CMLC1 antibody
    • ELC of myosin antibody
    • Essential light chain of myosin antibody
    • MLC1SB antibody
    • MLC1V antibody
    • MYL3 antibody
    • MYL3_HUMAN antibody
    • Myosin light chain 1 antibody
    • Myosin light chain 1 slow twitch muscle B/ventricular isoform antibody
    • Myosin light chain 1 slow, B antibody
    • Myosin light chain 3 antibody
    • Myosin, light chain 1, ventricular antibody
    • myosin, light chain 3, alkali; ventricular, skeletal, slow antibody
    • myosin, light polypeptide 3, alkali antibody
    • myosin, light polypeptide 3, alkali; ventricular, skeletal, slow antibody
    • OTTHUMP00000165922 antibody
    • Slow skeletal ventricular myosin alkali light chain 3 antibody
    • slow-twitch muscle B/ventricular isoform antibody
    • Ventricular/slow twitch myosin alkali light chain antibody
    • VLC1 antibody
    see all

Images

  • Anti-Myosin light chain 3 antibody (ab137767) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size: 21 kDa



    12% SDS PAGE
  • Anti-Myosin light chain 3 antibody (ab137767) at 1/10000 dilution + Mouse heart whole cell lysate at 50 µg

    Predicted band size: 21 kDa



    12% SDS PAGE

References

This product has been referenced in:

See 1 Publication for this product

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