Anti-Myostatin Propeptide antibody (ab134682)
Key features and details
- Rabbit polyclonal to Myostatin Propeptide
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Myostatin Propeptide antibody
See all Myostatin Propeptide primary antibodies -
Description
Rabbit polyclonal to Myostatin Propeptide -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse
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Immunogen
Synthetic peptide corresponding to Human Myostatin Propeptide (N terminal). Immunogen is within the range of aa 38-87
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Positive control
- Human lung carcinoma tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol
PBS is without Mg2+ and Ca2+ -
Concentration information loading... -
Purity
Immunogen affinity purified -
Purification notes
ab134682 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab134682 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| Notes |
|---|
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IHC-P
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
Acts specifically as a negative regulator of skeletal muscle growth. -
Involvement in disease
Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. -
Sequence similarities
Belongs to the TGF-beta family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 2660 Human
- Entrez Gene: 17700 Mouse
- Omim: 601788 Human
- SwissProt: O14793 Human
- SwissProt: O08689 Mouse
- Unigene: 41565 Human
- Unigene: 3514 Mouse
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Alternative names
- Cmpt antibody
- GDF-8 antibody
- GDF8_HUMAN antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myostatin Propeptide antibody (ab134682)Immunohistochemical analysis of paraffin-embedded Human lung carcinoma tissue labelling Myostatin Propeptide with ab134682 at 1/50 dilution.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab134682 has been referenced in 2 publications.
- Scimeca M et al. Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia. J Transl Med 15:34 (2017). PubMed: 28202082
- Scimeca M et al. Satellite Cells CD44 Positive Drive Muscle Regeneration in Osteoarthritis Patients. Stem Cells Int 2015:469459 (2015). IHC . PubMed: 26101529