Anti-Myostatin Propeptide antibody (ab134682)

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Overview

  • Product name

    Anti-Myostatin Propeptide antibody
    See all Myostatin Propeptide primary antibodies

  • Description

    Rabbit polyclonal to Myostatin Propeptide

  • Host species

    Rabbit

  • Tested applications

    Suitable for: IHC-Pmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse

  • Immunogen

    Synthetic peptide corresponding to Human Myostatin Propeptide (N terminal). Immunogen is within the range of aa 38-87

  • Positive control

    • Human lung carcinoma tissue.

Properties

  • Form

    Liquid

  • Storage instructions

    Shipped at 4°C. Store at -20ºC.

  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 0.88% Sodium chloride, 50% Glycerol

    PBS is without Mg2+ and Ca2+
  • Concentration information loading...

  • Purity

    Immunogen affinity purified

  • Purification notes

    ab134682 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Research areas

Applications

Our Abpromise guarantee covers the use of ab134682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acts specifically as a negative regulator of skeletal muscle growth.

  • Involvement in disease

    Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

  • Sequence similarities

    Belongs to the TGF-beta family.

  • Cellular localization

    Secreted.
  • Information by UniProt

  • Database links

    • Alternative names

      • Cmpt antibody
      • GDF-8 antibody
      • GDF8_HUMAN antibody
      • Growth/differentiation factor 8 antibody
      • MSLHP antibody
      • MSTN antibody
      • MSTN myostatin antibody
      • Myostatin antibody
      • Myostatin Propeptide antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myostatin Propeptide antibody (ab134682)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myostatin Propeptide antibody (ab134682)
      Immunohistochemical analysis of paraffin-embedded Human lung carcinoma tissue labelling Myostatin Propeptide with ab134682 at 1/50 dilution.

    References

    This product has been referenced in:

    • Scimeca M  et al. Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia. J Transl Med 15:34 (2017). Read more (PubMed: 28202082) »
    • Scimeca M  et al. Satellite Cells CD44 Positive Drive Muscle Regeneration in Osteoarthritis Patients. Stem Cells Int 2015:469459 (2015). IHC . Read more (PubMed: 26101529) »
    See all 2 Publications for this product

    Publishing research using ab134682? Please let us know so that we can cite the reference in this datasheet.

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