Overview

  • Product name

    Anti-Myostatin Propeptide antibody
    See all Myostatin Propeptide primary antibodies
  • Description

    Rabbit polyclonal to Myostatin Propeptide
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to Human Myostatin Propeptide (N terminal). Immunogen is within the range of aa 38-87

  • Positive control

    • Human lung carcinoma tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at -20ºC.
  • Storage buffer

    pH: 7.40
    Preservative: 0.02% Sodium azide
    Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
    Note: PBS is without Mg2+ and Ca2+
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Purification notes

    ab134682 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab134682 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acts specifically as a negative regulator of skeletal muscle growth.
  • Involvement in disease

    Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.
  • Sequence similarities

    Belongs to the TGF-beta family.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cmpt antibody
    • GDF-8 antibody
    • GDF8_HUMAN antibody
    • Growth/differentiation factor 8 antibody
    • MSLHP antibody
    • MSTN antibody
    • MSTN myostatin antibody
    • Myostatin antibody
    • Myostatin Propeptide antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human lung carcinoma tissue labelling Myostatin Propeptide with ab134682 at 1/50 dilution.

References

This product has been referenced in:

  • Scimeca M  et al. Bone Morphogenetic Proteins and myostatin pathways: key mediator of human sarcopenia. J Transl Med 15:34 (2017). Read more (PubMed: 28202082) »
  • Scimeca M  et al. Satellite Cells CD44 Positive Drive Muscle Regeneration in Osteoarthritis Patients. Stem Cells Int 2015:469459 (2015). IHC . Read more (PubMed: 26101529) »
See all 2 Publications for this product

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