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Signal Transduction Cytoskeleton / ECM Cytoskeleton Microfilaments Actin etc Actin Crosslinking
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Anti-Myozenin 2 antibody (ab169641)

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Western blot - Anti-Myozenin 2 antibody (ab169641)

    Key features and details

    • Rabbit polyclonal to Myozenin 2
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Recombinant Human Myozenin 2 protein (ab172811)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-Myozenin 2 antibody
      See all Myozenin 2 primary antibodies
    • Description

      Rabbit polyclonal to Myozenin 2
    • Host species

      Rabbit
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Sheep, Cow, Pig, Chimpanzee, Orangutan
    • Immunogen

      Full length protein, corresponding to amino acids 1-264 of Human Myozenin 2 (NP_057683.1, UniProt ID: Q9NPC6)

      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Lysate from 293T cells transfected with Myozenin 2.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
    • Storage buffer

      pH: 7.4
      Constituent: 100% PBS
    • Concentration information loading...
    • Purity

      Protein A purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Cytoskeleton
      • Microfilaments
      • Actin etc
      • Actin Crosslinking
      • Cardiovascular
      • Heart
      • Contractility
      • Contractile Proteins
      • Actins

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human Myozenin 2 protein (ab172811)

    Applications

    Our Abpromise guarantee covers the use of ab169641 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.

    Target

    • Function

      Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
    • Tissue specificity

      Expressed specifically in heart and skeletal muscle.
    • Involvement in disease

      Defects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16) [MIM:613838]. CMH16 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similarities

      Belongs to the myozenin family.
    • Cellular localization

      Cytoplasm > myofibril > sarcomere > Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.
    • Target information above from: UniProt accession Q9NPC6 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 540487 Cow
      • Entrez Gene: 51778 Human
      • Entrez Gene: 59006 Mouse
      • Entrez Gene: 295426 Rat
      • Entrez Gene: 100526817 Sheep
      • Omim: 605602 Human
      • SwissProt: Q5E9V3 Cow
      • SwissProt: Q9NPC6 Human
      • SwissProt: Q9JJW5 Mouse
      • Unigene: 732122 Human
      • Unigene: 141157 Mouse
      • Unigene: 12931 Rat
      see all
    • Alternative names

      • C4orf5 antibody
      • Calcineurin binding protein calsarcin 1 antibody
      • Calsarcin 1 antibody
      • Calsarcin-1 antibody
      • Calsarcin1 antibody
      • CMH16 antibody
      • CS 1 antibody
      • CS1 antibody
      • FATZ related protein 2 antibody
      • FATZ-related protein 2 antibody
      • Muscle specific protein antibody
      • MYOZ 2 antibody
      • MYOZ2 antibody
      • MYOZ2_HUMAN antibody
      • Myozenin-2 antibody
      • Myozenin2 antibody
      see all

    Images

    • Western blot - Anti-Myozenin 2 antibody (ab169641)
      Western blot - Anti-Myozenin 2 antibody (ab169641)
      All lanes : Anti-Myozenin 2 antibody (ab169641) at 1 µg/ml

      Lane 1 : Myozenin 2-transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 15 µl per lane.

      Secondary
      All lanes : Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution

      Developed using the ECL technique.

      Predicted band size: 30 kDa

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab169641? Please let us know so that we can cite the reference in this datasheet.

    ab169641 has not yet been referenced specifically in any publications.

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