Overview

  • Product name
  • Description
    Rabbit polyclonal to Myozenin 2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Cow, Pig, Chimpanzee, Orangutan
  • Immunogen

    Full length protein, corresponding to amino acids 1-264 of Human Myozenin 2 (NP_057683.1, UniProt ID: Q9NPC6)

  • Positive control
    • Lysate from 293T cells transfected with Myozenin 2.

Properties

Applications

Our Abpromise guarantee covers the use of ab169641 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.

Target

  • Function
    Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.
  • Tissue specificity
    Expressed specifically in heart and skeletal muscle.
  • Involvement in disease
    Defects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16) [MIM:613838]. CMH16 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities
    Belongs to the myozenin family.
  • Cellular localization
    Cytoplasm > myofibril > sarcomere > Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.
  • Information by UniProt
  • Database links
  • Alternative names
    • C4orf5 antibody
    • Calcineurin binding protein calsarcin 1 antibody
    • Calsarcin 1 antibody
    • Calsarcin-1 antibody
    • Calsarcin1 antibody
    • CMH16 antibody
    • CS 1 antibody
    • CS1 antibody
    • FATZ related protein 2 antibody
    • FATZ-related protein 2 antibody
    • Muscle specific protein antibody
    • MYOZ 2 antibody
    • MYOZ2 antibody
    • MYOZ2_HUMAN antibody
    • Myozenin-2 antibody
    • Myozenin2 antibody
    see all

Images

  • All lanes : Anti-Myozenin 2 antibody (ab169641) at 1 µg/ml

    Lane 1 : Myozenin 2-transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution

    Developed using the ECL technique.

    Predicted band size: 30 kDa

References

ab169641 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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