Anti-Myozenin 2 antibody (ab169641)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-Myozenin 2 antibody
See all Myozenin 2 primary antibodies -
Description
Rabbit polyclonal to Myozenin 2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Cow, Pig, Chimpanzee, Orangutan
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Immunogen
Full length protein, corresponding to amino acids 1-264 of Human Myozenin 2 (NP_057683.1, UniProt ID: Q9NPC6)
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Positive control
- Lysate from 293T cells transfected with Myozenin 2.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.20
Constituent: 100% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab169641 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. |
Target
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Function
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. -
Tissue specificity
Expressed specifically in heart and skeletal muscle. -
Involvement in disease
Defects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16) [MIM:613838]. CMH16 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. -
Sequence similarities
Belongs to the myozenin family. -
Cellular localization
Cytoplasm > myofibril > sarcomere > Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. - Information by UniProt
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Database links
- Entrez Gene: 540487 Cow
- Entrez Gene: 51778 Human
- Entrez Gene: 59006 Mouse
- Entrez Gene: 295426 Rat
- Entrez Gene: 100526817 Sheep
- Omim: 605602 Human
- SwissProt: Q5E9V3 Cow
- SwissProt: Q9NPC6 Human
see all -
Alternative names
- C4orf5 antibody
- Calcineurin binding protein calsarcin 1 antibody
- Calsarcin 1 antibody
see all
Images
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Western blot - Anti-Myozenin 2 antibody (ab169641)All lanes : Anti-Myozenin 2 antibody (ab169641) at 1 µg/ml
Lane 1 : Myozenin 2-transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution
Developed using the ECL technique.
Predicted band size: 30 kDa
Protocols
Datasheets and documents
References
ab169641 has not yet been referenced specifically in any publications.
