Anti-Myozenin 2 antibody (ab169641)
Key features and details
- Rabbit polyclonal to Myozenin 2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Myozenin 2 antibody
See all Myozenin 2 primary antibodies -
Description
Rabbit polyclonal to Myozenin 2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Sheep, Cow, Pig, Chimpanzee, Orangutan
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Immunogen
Full length protein, corresponding to amino acids 1-264 of Human Myozenin 2 (NP_057683.1, UniProt ID: Q9NPC6)
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Positive control
- Lysate from 293T cells transfected with Myozenin 2.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.4
Constituent: 100% PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab169641 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. |
Target
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Function
Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. -
Tissue specificity
Expressed specifically in heart and skeletal muscle. -
Involvement in disease
Defects in MYOZ2 are the cause of familial hypertrophic cardiomyopathy type 16 (CMH16) [MIM:613838]. CMH16 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. -
Sequence similarities
Belongs to the myozenin family. -
Cellular localization
Cytoplasm > myofibril > sarcomere > Z line. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. - Information by UniProt
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Database links
- Entrez Gene: 540487 Cow
- Entrez Gene: 51778 Human
- Entrez Gene: 59006 Mouse
- Entrez Gene: 295426 Rat
- Entrez Gene: 100526817 Sheep
- Omim: 605602 Human
- SwissProt: Q5E9V3 Cow
- SwissProt: Q9NPC6 Human
see all -
Alternative names
- C4orf5 antibody
- Calcineurin binding protein calsarcin 1 antibody
- Calsarcin 1 antibody
see all
Images
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Western blot - Anti-Myozenin 2 antibody (ab169641)All lanes : Anti-Myozenin 2 antibody (ab169641) at 1 µg/ml
Lane 1 : Myozenin 2-transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 15 µl per lane.
Secondary
All lanes : Goat Anti-Rabbit IgG (H+L) at 1/7500 dilution
Developed using the ECL technique.
Predicted band size: 30 kDa
Datasheets and documents
References (0)
ab169641 has not yet been referenced specifically in any publications.
