Mz1, selectively degrades BRD4 (ab230371)
Key features and details
- (+)-JQ1 based PROTAC that selectively degrades BRD4
- CAS Number: 1797406-69-9
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Mz1, selectively degrades BRD4 -
Description
(+)-JQ1 based PROTAC that selectively degrades BRD4 -
Biological description
Cell penetrant PROTAC (Proteolysis Targeting Chimera) compound based on (+)-JQ1 (ab141498) tethered to a von Hippel-Lindau (VHL) ligand. Retains high affinity for BRD2, BRD3 and BRD4 bromodomains. Induces preferential degradation of BRD4 over BRD2 and BRD3 in HeLa cells.
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Purity
> 98% -
CAS Number
1797406-69-9 -
Chemical structure
Properties
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Chemical name
(2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2- f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide -
Molecular weight
1002.64 -
Molecular formula
C49H60ClN9O8S2 -
PubChem identifier
122201421 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
SMILES
CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCC(=O)NC(C(=O)N4CC(CC4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)C7=CC=C(C=C7)Cl)C -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab230371 has not yet been referenced specifically in any publications.
