N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride, protein kinase inhibitor (ab143763)

Overview

  • Product name

    N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride, protein kinase inhibitor
  • Description

    Potent, competitive protein kinase inhibitor.
  • Alternative names

    • H-9 hydrochloride
    • HCl
    • N-(2-Aminoethyl)-5-isoquinolinesulfonamide
    • Protein Kinase Inhibitor H-9
  • Biological description

    Potent competitive inhibitor of protein kinase C, cGMP-dependent protein kinase and cAMP-dependent protein kinase (Ki = 18, 0.87, and 1.9 µM, respectively). Has been used to reduce the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons.

  • CAS Number

    116970-50-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride
  • Molecular weight

    287.77
  • Molecular formula

    C11H13N3O2S.HCl
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Papaioannou S  et al. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Invert Neurosci 8:91-100 (2008). Read more (PubMed: 18463910) »
  • Inagaki M  et al. N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases. J Biol Chem 260:2922-5 (1985). Read more (PubMed: 2982842) »

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