N-(3-Oxododecanoyl)-L-homoserine lactone, involved in quorum sensing (ab145509)

Overview

  • Product name

    N-(3-Oxododecanoyl)-L-homoserine lactone, involved in quorum sensing
  • Description

    Autoinducer involved in quorum sensing by Pseudomonas aeruginosa.
  • Alternative names

    • 3-Oxo-C12-HSL
    • 3-Oxo-C12-HSL
    • 3-Oxo-N-[(3S)-2-oxotetrahydro-3-furanyl]dodecanamide
    • 3O-C12-HSL
    • 3OC12HSL
    • AHL-12
    • C12
    • C12-HSL
    • N-(3-Oxododecanoyl)homoserine lactone
    • N-3-oxo-dodecanoyl-L-Homoserine lactone
    see all
  • Biological description

    Autoinducer involved in quorum sensing by Pseudomonas aeruginosa. Member of N-acyl-homoserine lactone (AHL) family that regulate gene expression in gram-negative bacteria and are involved in the processes of bacterial quorum sensing.

  • Purity

    > 98%
  • CAS Number

    168982-69-2
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    297.39
  • Molecular formula

    C16H27NO4
  • Storage instructions

    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Tao S  et al. Paraoxonase 2 modulates a proapoptotic function in LS174T cells in response to quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Sci Rep 6:28778 (2016). Read more (PubMed: 27364593) »
  • Maurer S  et al. Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone. Front Immunol 6:369 (2015). Read more (PubMed: 26257736) »
  • Bortolotti D  et al. Pseudomonas aeruginosa Quorum Sensing Molecule N-(3-Oxododecanoyl)-L-Homoserine-Lactone Induces HLA-G Expression in Human Immune Cells. Infect Immun 83:3918-25 (2015). Read more (PubMed: 26195547) »
  • Li Y  et al. N-3-(oxododecanoyl)-L-homoserine lactone promotes the induction of regulatory T-cells by preventing human dendritic cell maturation. Exp Biol Med (Maywood) 240:896-903 (2015). Read more (PubMed: 25749498) »

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