N-Acetylphytosphingosine (NAPS), Sphingolipid ceramide derivative (ab144126)

Overview

  • Product name

    N-Acetylphytosphingosine (NAPS), Sphingolipid ceramide derivative
  • Description

    Sphingolipid ceramide derivative
  • Alternative names

    • NAPS
  • Biological description

    Sphingolipid ceramide derivative. Induces caspase-dependent apoptosis. Anticancer agent. Potential NF-κB and JAK/STAT signaling inhibitor. Active in vitro and potentially in vivo.
  • Purity

    > 98%
  • CAS Number

    475995-69-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[(2R,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]acetamide

  • Molecular weight

    359.55
  • Molecular formula

    C20H41NO4
  • PubChem identifier

    10451108
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO (with warming)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)C)O)O
  • Source

    Pichia ciferri

References

This product has been referenced in:

  • Kim BH  et al. Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-?B and JAK/STAT signaling in keratinocytes and mice. J Invest Dermatol 134:1023-32 (2014). Read more (PubMed: 24177187) »
  • Han Y  et al. N-acetylphytosphingosine enhances the radiosensitivity of lung cancer cell line NCI-H460. Mol Cells 25:224-30 (2008). Read more (PubMed: 18414010) »
  • Han Y  et al. N-acetylphytosphingosine-induced apoptosis of Jurkat cells is mediated by the conformational change in Bak. Apoptosis 11:581-8 (2006). Read more (PubMed: 16528476) »

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