Anti-N Cadherin antibody (ab76057)
Key features and details
- Rabbit polyclonal to N Cadherin
- Suitable for: IP
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-N Cadherin antibody
See all N Cadherin primary antibodies -
Description
Rabbit polyclonal to N Cadherin -
Host species
Rabbit -
Specificity
ab76057 does not crossreact with E Cadherin. -
Tested applications
Suitable for: IPmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Chicken, Chimpanzee -
Immunogen
Unphosphorylated synthetic peptide:
ERPIHAEPQYPVRS
, corresponding to amino acids 811-824 of Human N Cadherin (coupled to a carrier protein). This sequence is conserved in rat and mouse N cadherin, and has three amino acid differences from the conserved region in R Cadherin. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 50% Glycerol, PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab76057 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IP |
1/100.
|
Notes |
---|
IP
1/100. |
Target
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Function
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density. -
Sequence similarities
Contains 5 cadherin domains. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 414745 Chicken
- Entrez Gene: 12558 Mouse
- Entrez Gene: 83501 Rat
- SwissProt: P10288 Chicken
- SwissProt: P15116 Mouse
- SwissProt: Q9Z1Y3 Rat
- Unigene: 257437 Mouse
- Unigene: 23200 Rat
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Alternative names
- CADH2_HUMAN antibody
- Cadherin 2 antibody
- Cadherin 2 N cadherin neuronal antibody
see all
Images
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Western blot image of mouse brain lysate immunoprecipitated with no antibody (lane 1), anti-N-Cadherin (CP1751) rabbit polyclonal antibody (lane 2), and whole mouse brain lysate (lane 3). The blot was probed with anti-N-cadherin (Cytoplasmic) mouse monoclonal antibody (lanes 1-3) and detected using anti-Mouse Ig Light Chain specific:HRP secondary antibody.
Datasheets and documents
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SDS download
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Datasheet download
References (196)
ab76057 has been referenced in 196 publications.
- Qi C et al. LncRNA NORAD facilitates oral squamous cell carcinoma progression by sponging miR-577 to enhance TPM4. Biol Direct 17:1 (2022). PubMed: 34991683
- Jiang B et al. circEPS15 Overexpression in Hepatocellular Carcinoma Modulates Tumor Invasion and Migration. Front Genet 13:804848 (2022). PubMed: 35211158
- Burgess ER et al. Increased Ascorbate Content of Glioblastoma Is Associated With a Suppressed Hypoxic Response and Improved Patient Survival. Front Oncol 12:829524 (2022). PubMed: 35419292
- Liu M et al. USP18 contributes to the proliferation and migration of ovarian cancer cells by regulating the AKT/mTOR signaling pathway. Acta Biochim Pol 69:417-422 (2022). PubMed: 35696596
- Zhou L et al. Identification and verification of the role of crucial genes through which methionine restriction inhibits the progression of colon cancer cells. Oncol Lett 24:274 (2022). PubMed: 35782898