N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist. (ab120026)

Overview

  • Product name

    N-Desmethyl clozapine (Normethylclozapine), Clozapine metabolite. M1 agonist. D2/D3 agonist.
  • Description

    Clozapine metabolite. M1 agonist. D2/D3 agonist.
  • Alternative names

    • Normethylclozapine
  • Biological description

    Brain penetrant metabolite of the atypical antipsychotic clozapine. Broad range of actions. Potent allosteric M1 partial agonist (IC50 = 55 nM for inhibition of [3H]-NMS binding). D2/D3 partial agonist. Also displays affinity at 5-HT1 and 5-HT2.
  • Purity

    > 99%
  • CAS Number

    6104-71-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Burstein ES  et al. Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther 315:1278-87 (2005). Read more (PubMed: 16135699) »
  • Sur C  et al. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A 100:13674-9 (2003). Read more (PubMed: 14595031) »
  • Fox S & Brotchie J Normethylclozapine potentiates the action of quinpirole in the 6-hydroxydopamine lesioned rat. Eur J Pharmacol 301:27-30 (1996). Read more (PubMed: 8773443) »

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