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    n-formyl-met-leu-phe-endogenous-chemotactic-peptide-ab141806.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)

  • Datasheet
  • SDS
  • COA
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Functional Studies - N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)

    Key features and details

    • Potent endogenous chemotactic peptide
    • CAS Number: 59880-97-6
    • Purity: > 98%
    • Soluble in ethanol to 5 mM and in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide
    • Description

      Potent endogenous chemotactic peptide
    • Biological description

      Potent endogenous chemotactic peptide and agonist for the formyl peptide receptor 1 (FPR1) (Ki = 38 nM). Chemoattractant for phagocytic leukocytes. Stimulates random and directed locomotion. Inducer of superoxide release. Active in vitro.

    • Purity

      > 98%
    • CAS Number

      59880-97-6
    • Chemical structure

      Chemical Structure

    Properties

    • Molecular weight

      437.55
    • Molecular formula

      C21H31N3O5S
    • Sequence

      MLF (Modifications: N-terminal formyl)
    • PubChem identifier

      443295
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in ethanol to 5 mM and in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)O)NC(=O)C(CCSC)NC=O
    • Source

      Synthetic

    • Research areas

      • Immunology
      • Innate Immunity
      • Macrophage / Inflamm.
      • Signal Transduction
      • Signaling Pathway
      • G Protein Signaling
      • GPCR
      • Cardiovascular
      • Atherosclerosis
      • Vascular Inflammation
      • Innate and adaptive immunity
      • Cardiovascular
      • Atherosclerosis
      • Vascular Inflammation
      • Leukocyte recruitment
      • Cell adhesion molecules
      • Biochemicals
      • Product Range
      • New
      • Biochemicals
      • Chemical Type
      • Biochemicals

    Associated products

      Images

      • Functional Studies - N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)
        Functional Studies - N-Formyl-Met-Leu-Phe, endogenous chemotactic peptide (ab141806)
        N-Formyl-Met-Leu-Phe activates Ca2+ transients in differentiated HL-60 cells.

        Cells were loaded with Fluo-3 AM (ab145254). Changes in intracellular Ca2+ were detected via changes in Fluo-3 emission following application (indicated by arrow) of 1 µM N-Formyl-Met-Leu-Phe (ab141806), (green) compared to control (black, saline perfusion).

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
      • SDS
      • COA
    • References (1)

      Publishing research using ab141806? Please let us know so that we can cite the reference in this datasheet.

      ab141806 has been referenced in 1 publication.

      • Cuesta Torres LF  et al. High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer. Atherosclerosis 286:20-29 (2019). PubMed: 31096070

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