N-Methyl-4-aminobutyric acid, L-Carnitine beta-oxidation inhibitor (ab145016)

Overview

  • Product name

    N-Methyl-4-aminobutyric acid, L-Carnitine beta-oxidation inhibitor
  • Description

    Inhibits L-Carnitine from undergoing β-oxidation in mammals.
  • Alternative names

    • 4-(Methylamino)butanoic Acid
    • 4-(Methylamino)butyric Acid
    • N-Methyl-GABA
  • Biological description

    GABA derivative and hydrolysis product of N-methyl-2-pyrrolidinone. Product of nicotine catabolism in bacteria. Inhibits L-Carnitine uptake in cultured rat cortical neurons.

  • CAS Number

    1119-48-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(Methylamino)butanoic acid
  • Molecular weight

    117.15
  • Molecular formula

    C5H11NO2
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    DMSO (with heating), Water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Chiribau CB  et al. Characterization of PmfR, the transcriptional activator of the pAO1-borne purU-mabO-folD operon of Arthrobacter nicotinovorans. J Bacteriol 187:3062-70 (2005). Read more (PubMed: 15838033) »
  • Virmani MA  et al. Structural, metabolic and ionic requirements for the uptake of L-carnitine by primary rat cortical cells. Pharmacol Res 33:19-27 (1996). Read more (PubMed: 8817642) »
  • Wells DA  et al. Mutagenicity and cytotoxicity of N-methyl-2-pyrrolidinone and 4-(methylamino)butanoic acid in the Salmonella/microsome assay. J Appl Toxicol 8:135-9 (1988). Read more (PubMed: 3288686) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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