Product nameN-Methyl-4-aminobutyric acid, L-Carnitine beta-oxidation inhibitor
DescriptionInhibits L-Carnitine from undergoing β-oxidation in mammals.
- 4-(Methylamino)butanoic Acid
- 4-(Methylamino)butyric Acid
GABA derivative and hydrolysis product of N-methyl-2-pyrrolidinone. Product of nicotine catabolism in bacteria. Inhibits L-Carnitine uptake in cultured rat cortical neurons.
Chemical name4-(Methylamino)butanoic acid
Storage instructionsStore at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewDMSO (with heating), Water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Chiribau CB et al. Characterization of PmfR, the transcriptional activator of the pAO1-borne purU-mabO-folD operon of Arthrobacter nicotinovorans. J Bacteriol 187:3062-70 (2005). Read more (PubMed: 15838033) »
- Virmani MA et al. Structural, metabolic and ionic requirements for the uptake of L-carnitine by primary rat cortical cells. Pharmacol Res 33:19-27 (1996). Read more (PubMed: 8817642) »
- Wells DA et al. Mutagenicity and cytotoxicity of N-methyl-2-pyrrolidinone and 4-(methylamino)butanoic acid in the Salmonella/microsome assay. J Appl Toxicol 8:135-9 (1988). Read more (PubMed: 3288686) »