N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin (ab144783)

Overview

  • Product name

    N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin
  • Description

    Dopaminergic selective neurotoxin
  • Alternative names

    • MPP+
  • Biological description

    Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects in vivo.
  • Purity

    > 98%
  • CAS Number

    36913-39-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Arshad A  et al. TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity. Acta Biochim Biophys Sin (Shanghai) 46:22-30 (2014). Read more (PubMed: 24252728) »
  • Haobam R  et al. Embryonic stem cells derived neuron transplantation recovery in models of parkinsonism in relation to severity of the disorder in rats. Rejuvenation Res : (2014). Read more (PubMed: 25546608) »
  • Kim-Han JS  et al. The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 31:7212-21 (2011). Read more (PubMed: 21562285) »

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