N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin (ab144783)
Key features and details
- Dopaminergic selective neurotoxin
- CAS Number: 36913-39-0
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
N-Methyl-4-phenylpyridinium Iodide (MPP+), Dopaminergic selective neurotoxin -
Description
Dopaminergic selective neurotoxin -
Alternative names
- MPP+
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Biological description
Dopaminergic selective neurotoxin. Active MPTP metabolite. Interferes with oxidative phosphorylation and induces mitochondrial dysfunction. Deplete cellular ATP. Shows Parkinson effects in vivo.
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Purity
> 98% -
CAS Number
36913-39-0 -
Chemical structure
Properties
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Chemical name
1-Methyl-4-phenylpyridin-1-ium iodide -
Molecular weight
297.13 -
Molecular formula
C12H12IN -
PubChem identifier
10924457 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. -
Solubility overview
Soluble in water to 100 mM -
Handling
Unstable; make up solutions fresh and use immediately.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-] -
Source
Synthetic
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Research areas
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (3)
ab144783 has been referenced in 3 publications.
- You W et al. Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release. Sci Rep 13:11045 (2023). PubMed: 37422517
- Zhou P et al. A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets. Cell Rep 32:108020 (2020). PubMed: 32783942
- Liu W et al. MiR-19b alleviates MPP+-induced neuronal cytotoxicity via targeting the HAPLN4/MAPK pathway in SH-SY5Y cells. RSC Adv 8:10706-10714 (2018). PubMed: 35540477