Key features and details
- Intracellular calcium channel blocker
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameN-methyl verapamil bromide
DescriptionIntracellular calcium channel blocker
Membrane impermeant verapamil derivative. Intracellular calcium channel blocker. Tonically blocks L-type channels in the inner pore with micromolar affinity. Affinity increases at depolarized membrane potentials. In T-type calcium channels, it blocks with micromolar affinity and has modestly increased affinity at depolarized potentials.
Storage instructionsStore at Room Temperature. Store at Room Temperature.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab147459 has been referenced in 3 publications.
- Ferrarese L et al. Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo. Cell Rep 24:3455-3465.e5 (2018). PubMed: 30257207
- Bergson P et al. Verapamil block of T-type calcium channels. Mol Pharmacol 79:411-9 (2011). PubMed: 21149638
- Zhang S et al. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ Res 84:989-98 (1999). PubMed: 10325236