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I would like to find an antibody that is specific of the N-terminal part of the MYCN protein and which is suitable for IP. I would be interested in purchasing the ab16898 MYCN antibody (NCM II 100) but I would like first to know which part of the MYCN protein does this antibody recognize (N-Term, C-Term?).
Asked on Jul 13 2006
Thank you for your enquiry. This antibody has been characterised with others raised against NMYC in the following paper which may be of help to you: Identification and characterisation of the NMYC gene product in human neuroblastoma cells by monoclonal antibodies with defined specificities. Ikegaki N et al. Prodedings of National Acadamy of Science USA. 83 p5929. This indiates that epitope for this antibody lies in the second exon of NMYC and it will recognise the cleavage products from NMYC. I hope this helps. Please get in touch again if you require any more advice. With thanks
Answered on Jul 17 2006