N-Nitrosodibenzylamine (NDBzA), Micronucleus-inducing mitogenic agent (ab144790)

Overview

  • Product name

    N-Nitrosodibenzylamine (NDBzA), Micronucleus-inducing mitogenic agent
  • Description

    Micronucleus-inducing mitogenic agent
  • Alternative names

    • NDBzA
  • Biological description

    Micronucleus-inducing mitogenic agent. Mutagenic to Salmonella typhimurium. Genotoxic to rat hepatocytes. Active in vitro and in vivo.
  • CAS Number

    5336-53-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N,N-Dibenzylnitrous amide
  • Molecular weight

    226.27
  • Molecular formula

    C14H14N2O
  • PubChem identifier

    21421
  • Storage instructions

    Store at -20°C. Store In the Dark. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CN(CC2=CC=CC=C2)N=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Jiao J  et al. Analysis of tissue-specific lacZ mutations induced by N-nitrosodibenzylamine in transgenic mice. Carcinogenesis 18:2239-45 (1997). Read more (PubMed: 9395227) »
  • Appel KE  et al. Metabolic denitrosation of N-nitrosamines: mechanism and biological consequences. IARC Sci Publ :351-7 (1991). Read more (PubMed: 1855879) »
  • Schmezer P  et al. Assay-specific genotoxicity of N-nitrosodibenzylamine to the rat liver in vivo. Environ Mol Mutagen 15:190-7 (1990). Read more (PubMed: 2192883) »

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