Overview

  • Product name

    n-Octyl caffeate, iNOS inhibitor
  • Description

    Potent antioxidant and iNOS inhibitor
  • Biological description

    Potent antioxidant and iNOS inhibitor (IC50 = 50 μM). Inhibits iron-catalyzed lipid peroxidation in vivo (IC50 = 1 μM). Suppresses activation of c-Jun-N-terminal kinase and extracellular signal-regulated kinase (IC50 = 50 μM). Chemopreventative agent. Orally active. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    478392-41-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Octyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
  • Molecular weight

    292.37
  • Molecular formula

    C17H24O4
  • PubChem identifier

    10108392
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCOC(=O)C=CC1=CC(=C(C=C1)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ujibe M  et al. Octylcaffeate induced apoptosis in human leukemia U937 cells. Biol Pharm Bull 28:2338-41 (2005). Read more (PubMed: 16327178) »
  • Hsiao G  et al. A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells. Biochem Pharmacol 65:1383-92 (2003). Read more (PubMed: 12694879) »
  • Nagaoka T  et al. Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-L5 carcinoma cells. Biol Pharm Bull 26:638-41 (2003). Read more (PubMed: 12736504) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab142448.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up