Key features and details
- Inhibitor of LPS-induced NF-κB DNA binding activity and COX-2 catalytic activity
- CAS Number: 3376-24-7
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameN-tert-Butyl-alpha-phenylnitrone (PBN)
DescriptionInhibitor of LPS-induced NF-κB DNA binding activity and COX-2 catalytic activity
Cell permeable free radicle trap. Inhibits LPS-induced NF-κB DNA binding activity, inhibits COX-2 catalytic activity and inhibits lipid peroxidation in rat liver microsomes. Blocks indiction of iNOS by reactive oxygen species.
Storage instructionsShipped at Room Temperature. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146814 has not yet been referenced specifically in any publications.