Recombinant Anti-NADPH oxidase 4 antibody [UOTR1B493] (ab133303)

Rabbit recombinant monoclonal NADPH oxidase 4 antibody [UOTR1B493]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Rat, Human. Cited in 49 publication(s). Independently reviewed in 13 review(s).

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ab133303 has been referenced in 73 publications.

  • Oglio R  et al. Participation of NADPH 4 oxidase in thyroid regulation. Mol Cell Endocrinol 480:65-73 (2019). PubMed: 30316800
  • Witten ML  et al. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132 (2019). PubMed: 30641074
  • Goh KY  et al. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox Biol 21:101100 (2019). PubMed: 30641298
  • Jiang T  et al. Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1. Mol Immunol 107:54-60 (2019). PubMed: 30660990
  • Kalainayakan SP  et al. Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression. Sci Rep 9:1405 (2019). PubMed: 30723259
  • Zhang J  et al. Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol 22:101116 (2019). PubMed: 30769285
  • Ge X  et al. Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury. Am J Transl Res 11:188-198 (2019). PubMed: 30787978
  • Chen P  et al. Palmitic acid-induced autophagy increases reactive oxygen species via the Ca2+/PKCa/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells. Exp Ther Med 17:2425-2432 (2019). PubMed: 30906429
  • Liang X  et al. Cyclic stretch induced oxidative stress by mitochondrial and NADPH oxidase in retinal pigment epithelial cells. BMC Ophthalmol 19:79 (2019). PubMed: 30885167
  • Kundumani-Sridharan V  et al. Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane. Am J Physiol Lung Cell Mol Physiol 316:L903-L917 (2019). PubMed: 30810065
  • Cheng Y  et al. MicroRNA-30e regulates TGF-ß-mediated NADPH oxidase 4-dependent oxidative stress by Snai1 in atherosclerosis. Int J Mol Med 43:1806-1816 (2019). PubMed: 30816428
  • Wang Z  et al. Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs. Oxid Med Cell Longev 2019:4628962 (2019). PubMed: 30944692
  • Zhang Y  et al. YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways. Front Pharmacol 10:381 (2019). PubMed: 31031629
  • Liu X  et al. Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. Artif Cells Nanomed Biotechnol 47:1628-1634 (2019). PubMed: 31010320
  • Jäger M  et al. Inducible Knockdown of Endothelial Protein Tyrosine Phosphatase-1B Promotes Neointima Formation in Obese Mice by Enhancing Endothelial Senescence. Antioxid Redox Signal 30:927-944 (2019). PubMed: 29390191
  • Montezano AC  et al. NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function. J Am Heart Assoc 7:N/A (2018). PubMed: 29907654
  • Jing W  et al. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. Am J Transl Res 10:2137-2147 (2018). PubMed: 30093950
  • Zhang Y  et al. Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells. Oxid Med Cell Longev 2018:4596746 (2018). PubMed: 30151070
  • Du S  et al. NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR. Cell Death Dis 9:948 (2018). PubMed: 30237423
  • Chen JR  et al. Renoprotective Effects of Antroquinonol in Rats with N?-Nitro-l-Arginine Methyl Ester-Induced Hypertension. Nutrients 10:N/A (2018). PubMed: 30336562
  • Li C  et al. Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats. Acta Pharmacol Sin 39:345-356 (2018). PubMed: 29119967
  • Battson ML  et al. Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction. Am J Physiol Endocrinol Metab 314:E468-E477 (2018). PubMed: 29351482
  • Koo YS  et al. Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress. Oxid Med Cell Longev 2018:2413841 (2018). PubMed: 30693061
  • Liu C  et al. Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-?B Signaling in Diabetic Rats. Front Pharmacol 9:1239 (2018). PubMed: 30459613
  • Zhu J  et al. Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate. Free Radic Biol Med 134:9-22 (2018). PubMed: 30599261
  • Li H  et al. Bicyclol Attenuates Liver Inflammation Induced by Infection of Hepatitis C Virus via Repressing ROS-Mediated Activation of MAPK/NF-?B Signaling Pathway. Front Pharmacol 9:1438 (2018). PubMed: 30618739
  • Xu H  et al. GATA4 protects against hyperglycemia-induced endothelial dysfunction by regulating NOX4 transcription. Mol Med Rep 17:1485-1492 (2018). PubMed: 29138836
  • Sureshbabu A  et al. RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. JCI Insight 3:N/A (2018). PubMed: 29875323
  • Yamada T  et al. Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats. Front Physiol 9:1111 (2018). PubMed: 30147660
  • Hou D  et al. Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. Redox Biol 17:99-111 (2018). PubMed: 29684820
  • He Y  et al. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell Death Dis 9:568 (2018). PubMed: 29752433
  • Zeng N  et al. Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. Exp Gerontol 110:23-34 (2018). WB . PubMed: 29751091
  • Daveri E  et al. Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biol 18:16-24 (2018). PubMed: 29890336
  • Lee J  et al. Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice. Physiol Rep 6:e13738 (2018). PubMed: 29932503
  • Zhang Z  et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis 24:274-285 (2018). PubMed: 29643724
  • Tang CT  et al. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cell Signal 46:52-63 (2018). IHC-P . PubMed: 29496628
  • Villar-Cheda B  et al. The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system. Cell Death Dis 8:e3044 (2017). WB ; Rat . PubMed: 28880266
  • Hammers DW  et al. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med 9:531-544 (2017). PubMed: 28270449
  • Lin XL  et al. Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer. Oncotarget 8:33586-33600 (2017). WB, IHC . PubMed: 28422720
  • Golden BO  et al. Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions. Oncotarget 8:107390-107408 (2017). PubMed: 29296173
  • Jing W  et al. LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD. Am J Transl Res 9:5473-5484 (2017). WB . PubMed: 29312499
  • Li X  et al. Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes. Sci Rep 7:14603 (2017). PubMed: 29097815
  • Murphy-Marshman H  et al. Antioxidants and NOX1/NOX4 inhibition blocks TGFß1-induced CCN2 and a-SMA expression in dermal and gingival fibroblasts. PLoS One 12:e0186740 (2017). PubMed: 29049376
  • Qi D  et al. Vaspin protects against LPS-induced ARDS by inhibiting inflammation, apoptosis and reactive oxygen species generation in pulmonary endothelial cells via the Akt/GSK-3ß pathway. Int J Mol Med 40:1803-1817 (2017). PubMed: 29039444
  • Wang M  et al. TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic ß-cells through the protein kinase C ß pathway. Int J Mol Med 40:130-136 (2017). WB ; Rat . PubMed: 28534945
  • Ju HQ  et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun 8:14437 (2017). WB . PubMed: 28232723
  • Majumder P  et al. Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario. Dis Model Mech 10:655-669 (2017). PubMed: 28360125
  • Li XZ  et al. Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress. Cell Physiol Biochem 44:2422-2438 (2017). PubMed: 29268252
  • Sun Q  et al. Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochim Biophys Acta Gen Subj 1861:2912-2921 (2017). PubMed: 27634671
  • Feng J  et al. Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. Oncotarget 8:10161-10170 (2017). PubMed: 28053285
  • Sweetwyne MT  et al. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int 91:1126-1145 (2017). PubMed: 28063595
  • Sun X  et al. NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells. J Appl Toxicol 37:1428-1437 (2017). PubMed: 28815642
  • Valenzuela R  et al. Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427 (2016). PubMed: 27763643
  • Cui F  et al. Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats. Evid Based Complement Alternat Med 2016:5957423 (2016). PubMed: 27672400
  • Chen H  et al. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biol 10:168-178 (2016). PubMed: 27750081
  • Hou Y  et al. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. Am J Physiol Renal Physiol 310:F547-59 (2016). PubMed: 26719366
  • Oh HJ  et al. Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy. Sci Rep 6:38789 (2016). PubMed: 27941951
  • Hakami NY  et al. Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. J Cell Mol Med 20:1932-44 (2016). WB ; Human . PubMed: 27297729
  • Kurlak LO  et al. Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. J Physiol 594:1327-40 (2016). IHC-P ; Human . PubMed: 26574162
  • Liu SH  et al. C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget 7:21900-12 (2016). PubMed: 26942460
  • Hood KY  et al. Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16a-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68:796-808 (2016). PubMed: 27402919
  • Moon JS  et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med 22:1002-12 (2016). PubMed: 27455510
  • Dong LH  et al. TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. Circ Res 117:684-94 (2015). PubMed: 26291555
  • Zhao P  et al. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4. Oxid Med Cell Longev 2015:645814 (2015). WB ; Rat . PubMed: 26347805
  • Weyemi U  et al. Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage. Radiat Res 183:262-70 (2015). PubMed: 25706776
  • Ullevig SL  et al. Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. Redox Biol 2:259-66 (2014). WB ; Human . PubMed: 24494201
  • Boudreau HE  et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-ß-mediated migration of human lung and breast epithelial cells. Br J Cancer 110:2569-82 (2014). Human . PubMed: 24714748
  • Carrillo-Sepulveda MA  et al. Role of vascular smooth muscle PPAR? in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS One 9:e103786 (2014). WB ; Mouse . PubMed: 25122005
  • Gölz L  et al. LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis. Mediators Inflamm 2014:986264 (2014). WB, IHC, ICC/IF ; Human . PubMed: 25374447
  • Peshavariya HM  et al. Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis. Antioxid Redox Signal 20:2710-25 (2014). PubMed: 24450852
  • Vázquez-Medina JP  et al. Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats. Am J Physiol Heart Circ Physiol 305:H599-607 (2013). WB ; Rat . PubMed: 23771688
  • Dorfmüller P  et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res 12:119 (2011). ICC/IF, IHC-Fr ; Rat . PubMed: 21906276
  • Lee CF  et al. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res 106:1489-97 (2010). PubMed: 20360249

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