Recombinant
RabMAb

Recombinant Anti-NADPH oxidase 4 antibody [UOTR1B493] (ab133303)

Rabbit recombinant monoclonal NADPH oxidase 4 antibody [UOTR1B493]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Rat, Human. Cited in 49 publication(s). Independently reviewed in 13 review(s).

Publishing research using ab133303? Please let us know so that we can cite the reference in this datasheet.

ab133303 has been referenced in 73 publications.

  • Oglio R  et al. Participation of NADPH 4 oxidase in thyroid regulation. Mol Cell Endocrinol 480:65-73 (2019). PubMed: 30316800
  • Witten ML  et al. Early life inhalation exposure to mine tailings dust affects lung development. Toxicol Appl Pharmacol 365:124-132 (2019). PubMed: 30641074
  • Goh KY  et al. Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice. Redox Biol 21:101100 (2019). PubMed: 30641298
  • Jiang T  et al. Anagliptin ameliorates high glucose- induced endothelial dysfunction via suppression of NLRP3 inflammasome activation mediated by SIRT1. Mol Immunol 107:54-60 (2019). PubMed: 30660990
  • Kalainayakan SP  et al. Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression. Sci Rep 9:1405 (2019). PubMed: 30723259
  • Zhang J  et al. Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol 22:101116 (2019). PubMed: 30769285
  • Ge X  et al. Inhibition of mitochondrial complex I by rotenone protects against acetaminophen-induced liver injury. Am J Transl Res 11:188-198 (2019). PubMed: 30787978
  • Chen P  et al. Palmitic acid-induced autophagy increases reactive oxygen species via the Ca2+/PKCa/NOX4 pathway and impairs endothelial function in human umbilical vein endothelial cells. Exp Ther Med 17:2425-2432 (2019). PubMed: 30906429
  • Liang X  et al. Cyclic stretch induced oxidative stress by mitochondrial and NADPH oxidase in retinal pigment epithelial cells. BMC Ophthalmol 19:79 (2019). PubMed: 30885167
  • Kundumani-Sridharan V  et al. Short-duration hyperoxia causes genotoxicity in mouse lungs: protection by volatile anesthetic isoflurane. Am J Physiol Lung Cell Mol Physiol 316:L903-L917 (2019). PubMed: 30810065
  • Cheng Y  et al. MicroRNA-30e regulates TGF-ß-mediated NADPH oxidase 4-dependent oxidative stress by Snai1 in atherosclerosis. Int J Mol Med 43:1806-1816 (2019). PubMed: 30816428
  • Wang Z  et al. Glycine Suppresses AGE/RAGE Signaling Pathway and Subsequent Oxidative Stress by Restoring Glo1 Function in the Aorta of Diabetic Rats and in HUVECs. Oxid Med Cell Longev 2019:4628962 (2019). PubMed: 30944692
  • Zhang Y  et al. YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways. Front Pharmacol 10:381 (2019). PubMed: 31031629
  • Liu X  et al. Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. Artif Cells Nanomed Biotechnol 47:1628-1634 (2019). PubMed: 31010320
  • Jäger M  et al. Inducible Knockdown of Endothelial Protein Tyrosine Phosphatase-1B Promotes Neointima Formation in Obese Mice by Enhancing Endothelial Senescence. Antioxid Redox Signal 30:927-944 (2019). PubMed: 29390191
  • Montezano AC  et al. NADPH Oxidase 5 Is a Pro-Contractile Nox Isoform and a Point of Cross-Talk for Calcium and Redox Signaling-Implications in Vascular Function. J Am Heart Assoc 7:N/A (2018). PubMed: 29907654
  • Jing W  et al. Uremia induces upregulation of cerebral tissue oxidative/inflammatory cascade, down-regulation of Nrf2 pathway and disruption of blood brain barrier. Am J Transl Res 10:2137-2147 (2018). PubMed: 30093950
  • Zhang Y  et al. Taurine Attenuates Calpain-2 Induction and a Series of Cell Damage via Suppression of NOX-Derived ROS in ARPE-19 Cells. Oxid Med Cell Longev 2018:4596746 (2018). PubMed: 30151070
  • Du S  et al. NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR. Cell Death Dis 9:948 (2018). PubMed: 30237423
  • Chen JR  et al. Renoprotective Effects of Antroquinonol in Rats with N?-Nitro-l-Arginine Methyl Ester-Induced Hypertension. Nutrients 10:N/A (2018). PubMed: 30336562
  • Li C  et al. Rhynchophylla total alkaloid rescues autophagy, decreases oxidative stress and improves endothelial vasodilation in spontaneous hypertensive rats. Acta Pharmacol Sin 39:345-356 (2018). PubMed: 29119967
  • Battson ML  et al. Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction. Am J Physiol Endocrinol Metab 314:E468-E477 (2018). PubMed: 29351482
  • Koo YS  et al. Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress. Oxid Med Cell Longev 2018:2413841 (2018). PubMed: 30693061
  • Liu C  et al. Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-?B Signaling in Diabetic Rats. Front Pharmacol 9:1239 (2018). PubMed: 30459613
  • Zhu J  et al. Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate. Free Radic Biol Med 134:9-22 (2018). PubMed: 30599261
  • Li H  et al. Bicyclol Attenuates Liver Inflammation Induced by Infection of Hepatitis C Virus via Repressing ROS-Mediated Activation of MAPK/NF-?B Signaling Pathway. Front Pharmacol 9:1438 (2018). PubMed: 30618739
  • Xu H  et al. GATA4 protects against hyperglycemia-induced endothelial dysfunction by regulating NOX4 transcription. Mol Med Rep 17:1485-1492 (2018). PubMed: 29138836
  • Sureshbabu A  et al. RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction. JCI Insight 3:N/A (2018). PubMed: 29875323
  • Yamada T  et al. Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats. Front Physiol 9:1111 (2018). PubMed: 30147660
  • Hou D  et al. Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer. Redox Biol 17:99-111 (2018). PubMed: 29684820
  • He Y  et al. Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Cell Death Dis 9:568 (2018). PubMed: 29752433
  • Zeng N  et al. Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis. Exp Gerontol 110:23-34 (2018). WB . PubMed: 29751091
  • Daveri E  et al. Cyanidin and delphinidin modulate inflammation and altered redox signaling improving insulin resistance in high fat-fed mice. Redox Biol 18:16-24 (2018). PubMed: 29890336
  • Lee J  et al. Physical activity protects NLRP3 inflammasome-associated coronary vascular dysfunction in obese mice. Physiol Rep 6:e13738 (2018). PubMed: 29932503
  • Zhang Z  et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis 24:274-285 (2018). PubMed: 29643724
  • Tang CT  et al. NOX4-driven ROS formation regulates proliferation and apoptosis of gastric cancer cells through the GLI1 pathway. Cell Signal 46:52-63 (2018). IHC-P . PubMed: 29496628
  • Villar-Cheda B  et al. The intracellular angiotensin system buffers deleterious effects of the extracellular paracrine system. Cell Death Dis 8:e3044 (2017). WB ; Rat . PubMed: 28880266
  • Hammers DW  et al. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med 9:531-544 (2017). PubMed: 28270449
  • Lin XL  et al. Overexpression of NOX4 predicts poor prognosis and promotes tumor progression in human colorectal cancer. Oncotarget 8:33586-33600 (2017). WB, IHC . PubMed: 28422720
  • Golden BO  et al. Extracellular superoxide dismutase inhibits hepatocyte growth factor-mediated breast cancer-fibroblast interactions. Oncotarget 8:107390-107408 (2017). PubMed: 29296173
  • Jing W  et al. LCZ696 (Sacubitril/valsartan) ameliorates oxidative stress, inflammation, fibrosis and improves renal function beyond angiotensin receptor blockade in CKD. Am J Transl Res 9:5473-5484 (2017). WB . PubMed: 29312499
  • Li X  et al. Puerarin attenuates diabetic kidney injury through the suppression of NOX4 expression in podocytes. Sci Rep 7:14603 (2017). PubMed: 29097815
  • Murphy-Marshman H  et al. Antioxidants and NOX1/NOX4 inhibition blocks TGFß1-induced CCN2 and a-SMA expression in dermal and gingival fibroblasts. PLoS One 12:e0186740 (2017). PubMed: 29049376
  • Qi D  et al. Vaspin protects against LPS-induced ARDS by inhibiting inflammation, apoptosis and reactive oxygen species generation in pulmonary endothelial cells via the Akt/GSK-3ß pathway. Int J Mol Med 40:1803-1817 (2017). PubMed: 29039444
  • Wang M  et al. TRB3 mediates advanced glycation end product-induced apoptosis of pancreatic ß-cells through the protein kinase C ß pathway. Int J Mol Med 40:130-136 (2017). WB ; Rat . PubMed: 28534945
  • Ju HQ  et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun 8:14437 (2017). WB . PubMed: 28232723
  • Majumder P  et al. Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario. Dis Model Mech 10:655-669 (2017). PubMed: 28360125
  • Li XZ  et al. Astragaloside IV Prevents Cardiac Remodeling in the Apolipoprotein E-Deficient Mice by Regulating Cardiac Homeostasis and Oxidative Stress. Cell Physiol Biochem 44:2422-2438 (2017). PubMed: 29268252
  • Sun Q  et al. Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochim Biophys Acta Gen Subj 1861:2912-2921 (2017). PubMed: 27634671
  • Feng J  et al. Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. Oncotarget 8:10161-10170 (2017). PubMed: 28053285
  • Sweetwyne MT  et al. The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int 91:1126-1145 (2017). PubMed: 28063595
  • Sun X  et al. NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells. J Appl Toxicol 37:1428-1437 (2017). PubMed: 28815642
  • Valenzuela R  et al. Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427 (2016). PubMed: 27763643
  • Cui F  et al. Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats. Evid Based Complement Alternat Med 2016:5957423 (2016). PubMed: 27672400
  • Chen H  et al. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biol 10:168-178 (2016). PubMed: 27750081
  • Hou Y  et al. Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy. Am J Physiol Renal Physiol 310:F547-59 (2016). PubMed: 26719366
  • Oh HJ  et al. Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy. Sci Rep 6:38789 (2016). PubMed: 27941951
  • Hakami NY  et al. Trichostatin A, a histone deacetylase inhibitor suppresses NADPH Oxidase 4-Derived Redox Signalling and Angiogenesis. J Cell Mol Med 20:1932-44 (2016). WB ; Human . PubMed: 27297729
  • Kurlak LO  et al. Human placental renin-angiotensin system in normotensive and pre-eclamptic pregnancies at high altitude and after acute hypoxia-reoxygenation insult. J Physiol 594:1327-40 (2016). IHC-P ; Human . PubMed: 26574162
  • Liu SH  et al. C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget 7:21900-12 (2016). PubMed: 26942460
  • Hood KY  et al. Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16a-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial Hypertension. Hypertension 68:796-808 (2016). PubMed: 27402919
  • Moon JS  et al. NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages. Nat Med 22:1002-12 (2016). PubMed: 27455510
  • Dong LH  et al. TRAF6-Mediated SM22a K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. Circ Res 117:684-94 (2015). PubMed: 26291555
  • Zhao P  et al. Total Glucosides of Danggui Buxue Tang Attenuate BLM-Induced Pulmonary Fibrosis via Regulating Oxidative Stress by Inhibiting NOX4. Oxid Med Cell Longev 2015:645814 (2015). WB ; Rat . PubMed: 26347805
  • Weyemi U  et al. Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage. Radiat Res 183:262-70 (2015). PubMed: 25706776
  • Ullevig SL  et al. Ursolic acid protects monocytes against metabolic stress-induced priming and dysfunction by preventing the induction of Nox4. Redox Biol 2:259-66 (2014). WB ; Human . PubMed: 24494201
  • Boudreau HE  et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-ß-mediated migration of human lung and breast epithelial cells. Br J Cancer 110:2569-82 (2014). Human . PubMed: 24714748
  • Carrillo-Sepulveda MA  et al. Role of vascular smooth muscle PPAR? in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. PLoS One 9:e103786 (2014). WB ; Mouse . PubMed: 25122005
  • Gölz L  et al. LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis. Mediators Inflamm 2014:986264 (2014). WB, IHC, ICC/IF ; Human . PubMed: 25374447
  • Peshavariya HM  et al. Prostacyclin signaling boosts NADPH oxidase 4 in the endothelium promoting cytoprotection and angiogenesis. Antioxid Redox Signal 20:2710-25 (2014). PubMed: 24450852
  • Vázquez-Medina JP  et al. Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats. Am J Physiol Heart Circ Physiol 305:H599-607 (2013). WB ; Rat . PubMed: 23771688
  • Dorfmüller P  et al. Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension. Respir Res 12:119 (2011). ICC/IF, IHC-Fr ; Rat . PubMed: 21906276
  • Lee CF  et al. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res 106:1489-97 (2010). PubMed: 20360249

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